tert-butyl(2S)-[(tert-butoxycarbonyl)amino]-3-phenylmethanesulfonyloxypropionate

Base Information

Chemical Name:tert-butyl(2S)-[(tert-butoxycarbonyl)amino]-3-phenylmethanesulfonyloxypropionate
CAS No.:459871-14-8
Molecular Formula:C₁₉H₂₉NO₇S
Molecular Weight:415.508
Hs Code.:

Synonyms:tert-butyl(2S)-[(tert-butoxycarbonyl)amino]-3-phenylmethanesulfonyloxypropionate

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Chemical Property of tert-butyl(2S)-[(tert-butoxycarbonyl)amino]-3-phenylmethanesulfonyloxypropionate

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Technology Process of tert-butyl(2S)-[(tert-butoxycarbonyl)amino]-3-phenylmethanesulfonyloxypropionate

There total 1 articles about tert-butyl(2S)-[(tert-butoxycarbonyl)amino]-3-phenylmethanesulfonyloxypropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 71630-31-4,7738-22-9
N-(tert-butyloxycarbonyl)-L-serine tert-butyl ester

: 1939-99-7
benzenesulfonyl chloride

: 459871-14-8
tert-butyl(2S)-[(tert-butoxycarbonyl)amino]-3-phenylmethanesulfonyloxypropionate

Guidance literature:: In pyridine; at 25 ℃; for 0.0833333h;
DOI:10.1021/ja012741l

Reference yield: 70.0%

: 459871-14-8
tert-butyl(2S)-[(tert-butoxycarbonyl)amino]-3-phenylmethanesulfonyloxypropionate

: 108492-14-4,108283-48-3
tert-butyl (S)-3-azido-2-((tert-butoxycarbonyl)amino)propanoate

Guidance literature:: With sodium azide; tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 70 ℃; for 0.166667h;
DOI:10.1021/ja012741l

Reference yield:

: 459871-14-8
tert-butyl(2S)-[(tert-butoxycarbonyl)amino]-3-phenylmethanesulfonyloxypropionate

: 459871-11-5
N^α-(tert-butoxycarbonyl)-N^β-[3(S)-(4-amino-6-carboethoxy-5-methylpyrimidin-2-yl)-1-[(4S,5R)-4-methyl-5-phenyl-2-oxazolidinyl]propion-3-yl]-(S)-β-aminoalanine tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 70 percent / NaN₃; tetrabutylammonium bromide / dimethylformamide / 0.17 h / 70 °C

2.1: 95 percent / H₂ / Pd/C / ethanol / 15 h / 25 °C

3.1: 97 percent / 3 A molecular sieves / acetonitrile / 24 h

4.1: Sn(OTf)2; diisopropylethylamine / tetrahydrofuran / -78 - -20 °C

4.2: 45 percent / tetrahydrofuran / 2 h / -5 °C

5.1: 72 percent / Bu₃SnH; AIBN / benzene / 2 h / 80 °C

With tin(II) trifluoromethanesulfonate; sodium azide; 2,2'-azobis(isobutyronitrile); 3 A molecular sieve; tetrabutylammomium bromide; hydrogen; tri-n-butyl-tin hydride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/ja012741l