ethyl 4-hydroxy-2-(4-methoxy-2-methylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate

Base Information

• Chemical Name: ethyl 4-hydroxy-2-(4-methoxy-2-methylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate
• CAS No.: 941693-88-5
• Molecular Formula: C₂₀H₂₂N₂O₄
• Molecular Weight: 354.406

Synonyms:ethyl 4-hydroxy-2-(4-methoxy-2-methylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate

Chemical Property of ethyl 4-hydroxy-2-(4-methoxy-2-methylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate

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Technology Process of ethyl 4-hydroxy-2-(4-methoxy-2-methylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate

There total 2 articles about ethyl 4-hydroxy-2-(4-methoxy-2-methylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

Ethyl 1-amino-5-methyl-1H-pyrrole-3-carboxylate (941693-86-3) + ethyl 3-(4-methoxy-2-methyl-phenyl)-2-methyl-3-oxopropionate (1357010-62-8) → ethyl 4-hydroxy-2-(4-methoxy-2-methylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate (941693-88-5)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 36h; Reflux;

DOI:10.1016/j.bmc.2011.11.015

Reference yield:

Ethyl 1-amino-5-methyl-1H-pyrrole-3-carboxylate (941693-86-3) + Methyl 3-(4-methoxy-2-methylphenyl)-2-methyl-3-oxopropanoate (941693-87-4) → ethyl 4-hydroxy-2-(4-methoxy-2-methylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate (941693-88-5)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 24h; Heating / reflux;

Reference yield: 76.0%

ethyl 4-hydroxy-2-(4-methoxy-2-methylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate (941693-88-5) → ethyl 4-chloro-2-(4-methoxy-2-methylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate (941693-89-6)

Guidance literature:

With tetrachloromethane; triphenylphosphine; In tetrahydrofuran; for 2.5h; Reflux;

DOI:10.1016/j.bmc.2011.11.015

upstream raw materials:

Ethyl 1-amino-5-methyl-1H-pyrrole-3-carboxylate

Methyl 3-(4-methoxy-2-methylphenyl)-2-methyl-3-oxopropanoate

ethyl 3-(4-methoxy-2-methyl-phenyl)-2-methyl-3-oxopropionate

Downstream raw materials:

ethyl 4-chloro-2-(4-methoxy-2-methylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate

ethyl 2-(4-methoxy-2-methylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate

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