1-(3,4-bis-benzyloxy-phenyl)-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinolin-3-one

Base Information

• Chemical Name: 1-(3,4-bis-benzyloxy-phenyl)-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinolin-3-one
• CAS No.: 39949-82-1
• Molecular Formula: C₃₁H₂₇NO₄
• Molecular Weight: 477.56

Synonyms:1-(3,4-bis-benzyloxy-phenyl)-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinolin-3-one

Chemical Property of 1-(3,4-bis-benzyloxy-phenyl)-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinolin-3-one

Chemical Property:

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Technology Process of 1-(3,4-bis-benzyloxy-phenyl)-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinolin-3-one

There total 3 articles about 1-(3,4-bis-benzyloxy-phenyl)-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinolin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3,4-bis-benzyloxy-phenyl)-oxazolo[4,3-a]isoquinolin-3-one (39949-79-6) → 1-(3,4-bis-benzyloxy-phenyl)-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinolin-3-one (39949-82-1)

Guidance literature:

With hydrogen; platinum(IV) oxide; In tetrahydrofuran; acetic acid; for 32h; under 3102.9 Torr;

DOI:10.1021/jo00953a005

Reference yield:

3,4-dibenzyloxybenzaldehyde (5447-02-9) → 1-(3,4-bis-benzyloxy-phenyl)-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinolin-3-one (39949-82-1)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) NaH, DMF, (ii) NaBH₄, EtOH, (iii) aq. KOH, (iv) /BRN= 1098367/, Et₃N, CH₂Cl₂

2: H₂ / PtO₂ / acetic acid; tetrahydrofuran / 32 h / 3102.9 Torr

With hydrogen; platinum(IV) oxide; In tetrahydrofuran; acetic acid;

DOI:10.1021/jo00953a005

Reference yield:

2-benzoyl-1-cyano-1,2-dihydroisoquinoline (844-25-7,55839-33-3) → 1-(3,4-bis-benzyloxy-phenyl)-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinolin-3-one (39949-82-1)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) NaH, DMF, (ii) NaBH₄, EtOH, (iii) aq. KOH, (iv) /BRN= 1098367/, Et₃N, CH₂Cl₂

2: H₂ / PtO₂ / acetic acid; tetrahydrofuran / 32 h / 3102.9 Torr

With hydrogen; platinum(IV) oxide; In tetrahydrofuran; acetic acid;

DOI:10.1021/jo00953a005

upstream raw materials:

1-(3,4-bis-benzyloxy-phenyl)-oxazolo[4,3-a]isoquinolin-3-one

3,4-dibenzyloxybenzaldehyde

2-benzoyl-1-cyano-1,2-dihydroisoquinoline

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