5-[(2R,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-[2-(1H-indol-3-yl)-ethoxy]-3-(pyridin-4-ylmethoxy)-tetrahydro-pyran-2-ylmethoxy]-pentylamine

Base Information

Chemical Name:5-[(2R,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-[2-(1H-indol-3-yl)-ethoxy]-3-(pyridin-4-ylmethoxy)-tetrahydro-pyran-2-ylmethoxy]-pentylamine
CAS No.:543696-92-0
Molecular Formula:C₄₁H₄₉N₃O₆
Molecular Weight:679.857
Hs Code.:

Synonyms:5-[(2R,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-[2-(1H-indol-3-yl)-ethoxy]-3-(pyridin-4-ylmethoxy)-tetrahydro-pyran-2-ylmethoxy]-pentylamine

Suppliers and Price of 5-[(2R,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-[2-(1H-indol-3-yl)-ethoxy]-3-(pyridin-4-ylmethoxy)-tetrahydro-pyran-2-ylmethoxy]-pentylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-[(2R,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-[2-(1H-indol-3-yl)-ethoxy]-3-(pyridin-4-ylmethoxy)-tetrahydro-pyran-2-ylmethoxy]-pentylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-[(2R,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-[2-(1H-indol-3-yl)-ethoxy]-3-(pyridin-4-ylmethoxy)-tetrahydro-pyran-2-ylmethoxy]-pentylamine

There total 4 articles about 5-[(2R,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-[2-(1H-indol-3-yl)-ethoxy]-3-(pyridin-4-ylmethoxy)-tetrahydro-pyran-2-ylmethoxy]-pentylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 543697-19-4
5-[(2R,3R,4S,5R,6R)-6-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethoxy]-4,5-bis-benzyloxy-3-(pyridin-4-ylmethoxy)-tetrahydro-pyran-2-ylmethoxy]-pentylamine

: 543696-92-0
5-[(2R,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-[2-(1H-indol-3-yl)-ethoxy]-3-(pyridin-4-ylmethoxy)-tetrahydro-pyran-2-ylmethoxy]-pentylamine

Guidance literature:: With sodium hydroxide; In methanol; for 20h; Heating;
DOI:10.1021/jm0205088

Reference yield:

: 1822-51-1
4-picolylchloride hydrochloride

: 543696-92-0
5-[(2R,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-[2-(1H-indol-3-yl)-ethoxy]-3-(pyridin-4-ylmethoxy)-tetrahydro-pyran-2-ylmethoxy]-pentylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dimethylformamide / 0.5 h / 20 °C

1.2: 53 percent / sodium hydride; tetrabutylammonium iodide / tetrahydrofuran; dimethylformamide / 7 h

2.1: 66 percent / aq. triphenylphosphine / tetrahydrofuran / 3 h / Heating

3.1: 63 percent / aq. NaOH / methanol / 20 h / Heating

With sodium hydroxide; sodium hydride; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 2.1: Staudinger reduction;
DOI:10.1021/jm0205088

Reference yield:

: (2R,3R,4S,5R,6R)-2-(5-Azido-pentyloxymethyl)-6-[2-(1-benzenesulfonyl-1H-indol-3-yl)-ethoxy]-4,5-bis-benzyloxy-tetrahydro-pyran-3-ol

: 543696-92-0
5-[(2R,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-[2-(1H-indol-3-yl)-ethoxy]-3-(pyridin-4-ylmethoxy)-tetrahydro-pyran-2-ylmethoxy]-pentylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dimethylformamide / 0.5 h / 20 °C

1.2: 53 percent / sodium hydride; tetrabutylammonium iodide / tetrahydrofuran; dimethylformamide / 7 h

2.1: 66 percent / aq. triphenylphosphine / tetrahydrofuran / 3 h / Heating

3.1: 63 percent / aq. NaOH / methanol / 20 h / Heating

With sodium hydroxide; sodium hydride; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 2.1: Staudinger reduction;
DOI:10.1021/jm0205088