methyl 4-[5-(2,2’-dimethylbiphenyl-4-yl)-1,2,4-oxadiazol-3-yl]-2-fluorobenzoate

Base Information

Chemical Name:methyl 4-[5-(2,2’-dimethylbiphenyl-4-yl)-1,2,4-oxadiazol-3-yl]-2-fluorobenzoate
CAS No.:1141474-66-9
Molecular Formula:C₂₄H₁₉FN₂O₃
Molecular Weight:402.425
Hs Code.:

Synonyms:methyl 4-[5-(2,2’-dimethylbiphenyl-4-yl)-1,2,4-oxadiazol-3-yl]-2-fluorobenzoate

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Chemical Property of methyl 4-[5-(2,2’-dimethylbiphenyl-4-yl)-1,2,4-oxadiazol-3-yl]-2-fluorobenzoate

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Technology Process of methyl 4-[5-(2,2’-dimethylbiphenyl-4-yl)-1,2,4-oxadiazol-3-yl]-2-fluorobenzoate

There total 8 articles about methyl 4-[5-(2,2’-dimethylbiphenyl-4-yl)-1,2,4-oxadiazol-3-yl]-2-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69535-85-9
2,2’-dimethyl-1,1’-biphenyl-4-carboxylic acid

: 918967-55-2
methyl 4-[amino(hydroxyimino)methyl]-2-fluorobenzoate

: 1141474-66-9
methyl 4-[5-(2,2’-dimethylbiphenyl-4-yl)-1,2,4-oxadiazol-3-yl]-2-fluorobenzoate

Guidance literature:: 2,2’-dimethyl-1,1’-biphenyl-4-carboxylic acid; methyl 4-[amino(hydroxyimino)methyl]-2-fluorobenzoate; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; acetonitrile; at 20 ℃;

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile; at 150 ℃; for 0.5h; Microwave;

Reference yield:

: 148547-19-7
4-Bromo-3-methylbenzoic acid methyl ester

: 1141474-66-9
methyl 4-[5-(2,2’-dimethylbiphenyl-4-yl)-1,2,4-oxadiazol-3-yl]-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 6 h / 120 °C / Inert atmosphere

2: sodium hydroxide / water; tetrahydrofuran / 100 °C

3: coupling reagent / 0 - 20 °C / Inert atmosphere

4: acetonitrile / 0.5 h / 150 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; sodium hydroxide; In tetrahydrofuran; water; toluene; acetonitrile;
DOI:10.1002/cmdc.201402557

Reference yield:

: 909040-94-4
methyl 2,2'-dimethyl-1,1'-biphenyl-4-carboxylate

: 1141474-66-9
methyl 4-[5-(2,2’-dimethylbiphenyl-4-yl)-1,2,4-oxadiazol-3-yl]-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; tetrahydrofuran / 100 °C

2: coupling reagent / 0 - 20 °C / Inert atmosphere

3: acetonitrile / 0.5 h / 150 °C / Microwave irradiation

With sodium hydroxide; In tetrahydrofuran; water; acetonitrile;
DOI:10.1002/cmdc.201402557