3-azido-1-phenylheptane

Base Information

• Chemical Name: 3-azido-1-phenylheptane
• CAS No.: 1384450-62-7
• Molecular Formula: C₁₃H₁₉N₃
• Molecular Weight: 217.314
• Mol file: 1384450-62-7.mol

Synonyms:3-azido-1-phenylheptane

Chemical Property of 3-azido-1-phenylheptane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-azido-1-phenylheptane

There total 3 articles about 3-azido-1-phenylheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

1-phenylheptan-3-yl methanesulfonate → 3-azido-1-phenylheptane (1384450-62-7)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 70 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.joc.9b01887 DOI:10.1021/acs.joc.9b01887

Reference yield: 22.0%

1-phenylheptan-3-ol (19969-03-0) → 3-azido-1-phenylheptane (1384450-62-7)

Guidance literature:

With 2-azido-1,3-dimethyl-4,5-dihydro-1H-imidazol-3-ium hexafluorophosphate (V); sodium hydride; dimethyl sulfoxide; In tetrahydrofuran; at 0 ℃; for 1.5h;

DOI:10.1055/s-0031-1290958

Reference yield:

3-phenyl-propionaldehyde (104-53-0) → 3-azido-1-phenylheptane (1384450-62-7)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran; hexane / 20 h / -78 - 20 °C / Inert atmosphere

2: triethylamine / diethyl ether / 4 h / 0 - 20 °C

3: sodium azide / N,N-dimethyl-formamide / 2 h / 70 °C / Inert atmosphere

With sodium azide; triethylamine; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;

DOI:10.1021/acs.joc.9b01887 DOI:10.1021/acs.joc.9b01887

upstream raw materials:

1-phenylheptan-3-ol

3-phenyl-propionaldehyde