(2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-butyric acid ethyl ester

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Chemical Name:(2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-butyric acid ethyl ester
CAS No.:119588-76-0
Molecular Formula:C₂₀H₃₃NO₆Si
Molecular Weight:411.571
Hs Code.:

Synonyms:(2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-butyric acid ethyl ester

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Chemical Property of (2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-butyric acid ethyl ester

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Technology Process of (2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-butyric acid ethyl ester

There total 4 articles about (2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 119588-75-9
(2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-butyric acid ethyl ester

: 119588-76-0
(2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-butyric acid ethyl ester

Guidance literature:: With sodium tetrahydroborate; In methanol; water; at 0 ℃; for 0.25h;
DOI:10.1016/S0040-4020(01)86061-0

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 119588-76-0
(2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

2: 80 percent / calcium carbonate, methyl iodide / H₂O; acetone / 24 h / 60 °C

3: 85 percent / NaBH₄ / H₂O; methanol / 0.25 h / 0 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; calcium carbonate; methyl iodide; In methanol; dichloromethane; water; acetone;
DOI:10.1016/S0040-4020(01)86061-0

Reference yield:

: 119588-73-7
(2R,3S)-2-Benzyloxycarbonylamino-3-[1,3]dithiolan-2-yl-3-hydroxy-propionic acid ethyl ester

: 119588-76-0
(2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

2: 80 percent / calcium carbonate, methyl iodide / H₂O; acetone / 24 h / 60 °C

3: 85 percent / NaBH₄ / H₂O; methanol / 0.25 h / 0 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; calcium carbonate; methyl iodide; In methanol; dichloromethane; water; acetone;
DOI:10.1016/S0040-4020(01)86061-0