(S)-4-[1-Dimethylamino-meth-(E)-ylidene]-5-oxo-pyrrolidine-1,2-dicarboxylic acid dibenzyl ester

Base Information

• Chemical Name: (S)-4-[1-Dimethylamino-meth-(E)-ylidene]-5-oxo-pyrrolidine-1,2-dicarboxylic acid dibenzyl ester
• CAS No.: 71389-34-9
• Molecular Formula: C₂₃H₂₄N₂O₅
• Molecular Weight: 408.454

Synonyms:(S)-4-[1-Dimethylamino-meth-(E)-ylidene]-5-oxo-pyrrolidine-1,2-dicarboxylic acid dibenzyl ester

Chemical Property of (S)-4-[1-Dimethylamino-meth-(E)-ylidene]-5-oxo-pyrrolidine-1,2-dicarboxylic acid dibenzyl ester

Chemical Property:

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Technology Process of (S)-4-[1-Dimethylamino-meth-(E)-ylidene]-5-oxo-pyrrolidine-1,2-dicarboxylic acid dibenzyl ester

There total 1 articles about (S)-4-[1-Dimethylamino-meth-(E)-ylidene]-5-oxo-pyrrolidine-1,2-dicarboxylic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (S)-4-[1-Dimethylamino-meth-(E)-ylidene]-5-oxo-pyrrolidine-1,2-dicarboxylic acid dibenzyl ester (71389-34-9)

Guidance literature:

Ester 2, Bredereck's-Reagenz 3;

DOI:10.1021/ja00509a062

Reference yield:

(S)-4-[1-Dimethylamino-meth-(E)-ylidene]-5-oxo-pyrrolidine-1,2-dicarboxylic acid dibenzyl ester (71389-34-9) → γ-carboxy-L-glutamic acid (53861-57-7,53445-96-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (i), (ii) /BRN= 878307/, Et₃N

2: H₂ / Pd-C / methanol

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/ja00509a062

Reference yield:

(S)-4-[1-Dimethylamino-meth-(E)-ylidene]-5-oxo-pyrrolidine-1,2-dicarboxylic acid dibenzyl ester (71389-34-9) → (S)-4-[1-Hydroxy-meth-(Z)-ylidene]-5-oxo-pyrrolidine-1,2-dicarboxylic acid dibenzyl ester (78420-34-5)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/ja00396a070

Downstream raw materials:

(S)-2-Benzyloxycarbonyl-4-benzyloxycarbonylamino-pentanedioic acid dibenzyl ester

(S)-2-Benzyloxycarbonylamino-4-methoxycarbonyl-pentanedioic acid 1-benzyl ester 5-methyl ester

(S)-4-[1-Hydroxy-meth-(Z)-ylidene]-5-oxo-pyrrolidine-1,2-dicarboxylic acid dibenzyl ester

(S)-5-Oxo-4-[1-phenylsulfanyl-meth-(Z)-ylidene]-pyrrolidine-1,2-dicarboxylic acid dibenzyl ester

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