2-[4-(4-fluoro-benzyl)piperidin-1-ylmethyl]-3-nitro-benzoic acid methyl ester

Base Information

• Chemical Name: 2-[4-(4-fluoro-benzyl)piperidin-1-ylmethyl]-3-nitro-benzoic acid methyl ester
• CAS No.: 455260-00-1
• Molecular Formula: C₂₁H₂₃FN₂O₄
• Molecular Weight: 386.423

Synonyms:2-[4-(4-fluoro-benzyl)piperidin-1-ylmethyl]-3-nitro-benzoic acid methyl ester

Chemical Property of 2-[4-(4-fluoro-benzyl)piperidin-1-ylmethyl]-3-nitro-benzoic acid methyl ester

Chemical Property:

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Technology Process of 2-[4-(4-fluoro-benzyl)piperidin-1-ylmethyl]-3-nitro-benzoic acid methyl ester

There total 2 articles about 2-[4-(4-fluoro-benzyl)piperidin-1-ylmethyl]-3-nitro-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-fluorobenzyl)piperidine hydrochloride (92822-03-2) + 2-bromomethyl-3-nitro-benzoic acid methyl ester (98475-07-1) → 2-[4-(4-fluoro-benzyl)piperidin-1-ylmethyl]-3-nitro-benzoic acid methyl ester (455260-00-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1021/jm0201767

Reference yield:

2-methyl-3-nitro-benzoic acid methyl ester (59382-59-1) → 2-[4-(4-fluoro-benzyl)piperidin-1-ylmethyl]-3-nitro-benzoic acid methyl ester (455260-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / NBS; benzoyl peroxide / CCl₄ / 24 h / Heating

2: K₂CO₃ / dimethylformamide / 6 h / 20 °C

With N-Bromosuccinimide; potassium carbonate; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0201767

Reference yield: 100.0%

2-[4-(4-fluoro-benzyl)piperidin-1-ylmethyl]-3-nitro-benzoic acid methyl ester (455260-00-1) → 2-[4-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-3-nitro-benzoic acid (455260-01-2)

Guidance literature:

With sodium hydroxide; In methanol; for 2h; Heating;

DOI:10.1021/jm0201767

upstream raw materials:

4-(4-fluorobenzyl)piperidine hydrochloride

2-bromomethyl-3-nitro-benzoic acid methyl ester

2-methyl-3-nitro-benzoic acid methyl ester

Downstream raw materials:

3-amino-2-[4-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-benzoic acid methyl ester

2-[4-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-3-nitro-benzoic acid

2-[4-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-3-(3-phenyl-ureido)-benzoic acid methyl ester

3-[3-(3-acetyl-phenyl)-ureido]-2-[4-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-N-methyl-benzamide

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