2-methyl-4aα-(3-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydro-6β-isoquinolinol

Base Information

Chemical Name:2-methyl-4aα-(3-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydro-6β-isoquinolinol
CAS No.:118724-83-7
Molecular Formula:C₁₇H₂₃NO₂
Molecular Weight:273.375
Hs Code.:

Synonyms:2-methyl-4aα-(3-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydro-6β-isoquinolinol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methyl-4aα-(3-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydro-6β-isoquinolinol

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Technology Process of 2-methyl-4aα-(3-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydro-6β-isoquinolinol

There total 4 articles about 2-methyl-4aα-(3-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydro-6β-isoquinolinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 118724-77-9
(1S^*,3S^*,5S^*)-3-(2-bromoethyl)-5-(3-methoxyphenyl)-8-methyl-2-oxa-8-azabicyclo<3.3.1>nonane

: 118724-83-7
2-methyl-4aα-(3-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydro-6β-isoquinolinol

Guidance literature:: Multi-step reaction with 3 steps

1: 10.8 g / TFA / 1 h / Ambient temperature

2: K₂CO₃ / acetonitrile / 2 h / Heating

3: K₂CO₃, MeOH / 2 h / Ambient temperature

With methanol; potassium carbonate; trifluoroacetic acid; In acetonitrile;
DOI:10.1021/jo00267a039

Reference yield:

: 118724-79-1
Acetic acid (R)-3-bromo-1-[(R)-4-(3-methoxy-phenyl)-1-methyl-1,2,3,4-tetrahydro-pyridin-4-ylmethyl]-propyl ester

: 118724-83-7
2-methyl-4aα-(3-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydro-6β-isoquinolinol

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / acetonitrile / 2 h / Heating

2: K₂CO₃, MeOH / 2 h / Ambient temperature

With methanol; potassium carbonate; In acetonitrile;
DOI:10.1021/jo00267a039

Reference yield:

: 118724-76-8
(1S,3R,5R)-5-(3-Methoxy-phenyl)-8-methyl-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-2-oxa-8-aza-bicyclo[3.3.1]nonane; hydrochloride

: 118724-83-7
2-methyl-4aα-(3-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydro-6β-isoquinolinol

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / Ph₃P, Br₂ / tetrahydrofuran / 0.25 h / 10 - 20 °C

2: 10.8 g / TFA / 1 h / Ambient temperature

3: K₂CO₃ / acetonitrile / 2 h / Heating

4: K₂CO₃, MeOH / 2 h / Ambient temperature

With methanol; bromine; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jo00267a039