2,3-dihydro-2-methyl-2-(N-phenylbut-2-en-4-amide)-1H-indole

Base Information

• Chemical Name: 2,3-dihydro-2-methyl-2-(N-phenylbut-2-en-4-amide)-1H-indole
• CAS No.: 74590-90-2
• Molecular Formula: C₁₉H₂₀N₂O
• Molecular Weight: 292.381
• Mol file: 74590-90-2.mol

Synonyms:2,3-dihydro-2-methyl-2-(N-phenylbut-2-en-4-amide)-1H-indole

Chemical Property of 2,3-dihydro-2-methyl-2-(N-phenylbut-2-en-4-amide)-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2,3-dihydro-2-methyl-2-(N-phenylbut-2-en-4-amide)-1H-indole

There total 2 articles about 2,3-dihydro-2-methyl-2-(N-phenylbut-2-en-4-amide)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

aniline (62-53-3) → 2,3-dihydro-2-methyl-2-(N-phenylbut-2-en-4-amide)-1H-indole (74590-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / pyridine / diethyl ether / 1.) 0 deg C, 10 min, 2.) room temperature, 4 h

2: 1.) PdCl₂(CH₃CN)2, Na₂CO₃ / 1.) THF, reflux, 1.5 h, 2.) reflux

With pyridine; dichloro bis(acetonitrile) palladium(II); sodium carbonate; In diethyl ether;

DOI:10.1021/ja00530a044

Reference yield:

N-acryloylaniline (2210-24-4) + 2-(2-methylprop-2-en-1-yl)aniline (59816-87-4) → 2,3-dihydro-2-methyl-2-(N-phenylbut-2-en-4-amide)-1H-indole (74590-90-2)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); sodium carbonate; Yield given. Multistep reaction; 1.) THF, reflux, 1.5 h, 2.) reflux;

DOI:10.1021/ja00530a044

upstream raw materials:

N-acryloylaniline

2-(2-methylprop-2-en-1-yl)aniline

aniline