methyl (RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-fluorophenyl)acetate

Base Information

Chemical Name:methyl (RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-fluorophenyl)acetate
CAS No.:181040-24-4
Molecular Formula:C₂₁H₁₆FNO₄S
Molecular Weight:397.427
Hs Code.:

Synonyms:methyl (RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-fluorophenyl)acetate

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Chemical Property of methyl (RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-fluorophenyl)acetate

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Technology Process of methyl (RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-fluorophenyl)acetate

There total 6 articles about methyl (RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-fluorophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135660-93-4
α-bromo-o-fluorobenzoic acid methyl ester

: 170282-49-2
2-hydroxy-4-(thien-3-ylmethoxy)benzonitrile

: 181040-24-4
methyl (RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-fluorophenyl)acetate

Guidance literature:: 2-hydroxy-4-(thien-3-ylmethoxy)benzonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

α-bromo-o-fluorobenzoic acid methyl ester; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Further stages.;
DOI:10.1021/jm990378b

Reference yield:

: 389-31-1,32222-48-3,52950-13-7
2-fluoromandelic acid

: 181040-24-4
methyl (RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-fluorophenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂SO₄ / Heating

2.1: SOBr₂ / toluene / 20 °C

3.1: NaH / dimethylformamide / 0.17 h / 20 °C

3.2: dimethylformamide / 1 h / 20 °C

With sulfurous dibromide; sulfuric acid; sodium hydride; In N,N-dimethyl-formamide; toluene; 1.1: Esterification / 2.1: Bromination / 3.1: Metallation / 3.2: Substitution;
DOI:10.1021/jm990378b

Reference yield:

: 192884-55-2
methyl 2-(2-fluorophenyl)-2-hydroxyacetate

: 181040-24-4
methyl (RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-fluorophenyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: SOBr₂ / toluene / 20 °C

2.1: NaH / dimethylformamide / 0.17 h / 20 °C

2.2: dimethylformamide / 1 h / 20 °C

With sulfurous dibromide; sodium hydride; In N,N-dimethyl-formamide; toluene; 1.1: Bromination / 2.1: Metallation / 2.2: Substitution;
DOI:10.1021/jm990378b