3-[7-fluoro-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Base Information

Chemical Name:3-[7-fluoro-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene
CAS No.:1221349-40-1
Molecular Formula:C₂₂H₁₉F₄N₃O
Molecular Weight:417.406
Hs Code.:

Synonyms:3-[7-fluoro-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

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Chemical Property of 3-[7-fluoro-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

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Technology Process of 3-[7-fluoro-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

There total 6 articles about 3-[7-fluoro-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1015770-74-7
1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid ethyl ester

: 1221349-40-1
3-[7-fluoro-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydrochloride monohydrate; water / methanol / 16 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 20 °C

3.2: 3 h / 100 °C

With oxalyl dichloride; lithium hydrochloride monohydrate; water; triethylamine; N,N-dimethyl-formamide; In methanol; dichloromethane;
DOI:10.1021/jm101075v

Reference yield:

: 1259026-58-8
3-fluoro-5-nitro-2'-(trifluoromethyl)-[1.1'-biphenyl]-4-amine

: 1221349-40-1
3-[7-fluoro-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; iron / ethanol / 4 h / 80 °C

2.1: triethylamine / dichloromethane / 2 h / 20 °C

2.2: 3 h / 100 °C

With hydrogenchloride; iron; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/jm101075v

Reference yield:

: 517920-70-6
4-Bromo-2-fluoro-6-nitrobenzenamine

: 1221349-40-1
3-[7-fluoro-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane; water / 18 h / 90 °C / Inert atmosphere

2.1: hydrogenchloride; iron / ethanol / 4 h / 80 °C

3.1: triethylamine / dichloromethane / 2 h / 20 °C

3.2: 3 h / 100 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iron; sodium carbonate; triethylamine; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 1.1: Suzuki coupling;
DOI:10.1021/jm101075v