3-(aminomethyl)-1-N-(3-(N'-(3-isopropylureido))benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one

Base Information

Chemical Name:3-(aminomethyl)-1-N-(3-(N'-(3-isopropylureido))benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one
CAS No.:239097-82-6
Molecular Formula:C₂₂H₂₈N₄O₂
Molecular Weight:380.49
Hs Code.:

Synonyms:3-(aminomethyl)-1-N-(3-(N'-(3-isopropylureido))benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one

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Chemical Property of 3-(aminomethyl)-1-N-(3-(N'-(3-isopropylureido))benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one

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Technology Process of 3-(aminomethyl)-1-N-(3-(N'-(3-isopropylureido))benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one

There total 4 articles about 3-(aminomethyl)-1-N-(3-(N'-(3-isopropylureido))benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 239097-58-6
3-cyano-1-N-(3-(N'-(3-isopropylureido))benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one

: 239097-82-6
3-(aminomethyl)-1-N-(3-(N'-(3-isopropylureido))benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; under 2942.03 Torr;
DOI:10.1021/jm990044m

Reference yield:

: 86499-23-2
3-chloro-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one

: 239097-82-6
3-(aminomethyl)-1-N-(3-(N'-(3-isopropylureido))benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / tetra-n-butylammonium bromide, KOH / tetrahydrofuran / 2 h / Ambient temperature

2: 59 percent / n-Bu₄NBr / dimethylsulfoxide / 9 h / 115 °C

3: 67 percent / 12N aq. HCl, H₂ / 10 percent Pd/C / ethanol / 2942.03 Torr

With hydrogenchloride; potassium hydroxide; tetrabutylammomium bromide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1021/jm990044m

Reference yield:

: 1-(3-aminomethyl-phenyl)-3-isopropyl-urea

: 239097-82-6
3-(aminomethyl)-1-N-(3-(N'-(3-isopropylureido))benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / tetra-n-butylammonium bromide, KOH / tetrahydrofuran / 2 h / Ambient temperature

2: 59 percent / n-Bu₄NBr / dimethylsulfoxide / 9 h / 115 °C

3: 67 percent / 12N aq. HCl, H₂ / 10 percent Pd/C / ethanol / 2942.03 Torr

With hydrogenchloride; potassium hydroxide; tetrabutylammomium bromide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1021/jm990044m