2-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine

Base Information

• Chemical Name: 2-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine
• CAS No.: 13797-63-2
• Molecular Formula: C7H4F3N3
• Molecular Weight: 187.124
• Hs Code.: 2933990090
• European Community (EC) Number: 882-246-6
• DSSTox Substance ID: DTXSID90358800
• Nikkaji Number: J782.162J
• Wikidata: Q72512010
• Mol file: 13797-63-2.mol

Synonyms:13797-63-2;2-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine;2-Trifluoromethyl-3H-imidazo[4,5-b]pyridine;2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridine;trifluoromethylimidazopyridine;SCHEMBL10188120;DTXSID90358800;AMY15839;ZB0500;AKOS011056951;CS-0304110;2-(trifluoromethyl)-4H-imidazo[4,5-b]pyridine;EN300-26887793;J-506657;Z857667598

Chemical Property of 2-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine

Chemical Property:

• Vapor Pressure: 0.00688mmHg at 25°C
• Melting Point: 275-276℃
• Refractive Index: 1.565
• Boiling Point: 279.248 °C at 760 mmHg
• Flash Point: 122.685 °C
• PSA: 41.57000
• Density: 1.536 g/cm³
• LogP: 1.97670
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 187.03573163
• Heavy Atom Count: 13
• Complexity: 194

Purity/Quality:

98%Min ^*data from raw suppliers

2-(Trifluoromethyl)-3H-imidazo[4,5-b]pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(N=C1)N=C(N2)C(F)(F)F

Technology Process of 2-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine

There total 6 articles about 2-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,3-Diaminopyridine (452-58-4) + trifluoroacetic acid (76-05-1) → 2-Trifluoromethyl-3H-imidazo<4,5-b>pyridine (13797-63-2)

Guidance literature:

for 48h; Heating;

Reference yield: 76.0%

2,3-Diaminopyridine (452-58-4) + trifluoroacetic acid (76-05-1) → 2-(trifluoromethyl)-4H-imidazo[4,5-b]pyridine (13797-63-2)

Guidance literature:

at 110 ℃; for 15h; Microwave irradiation;

Reference yield: 42.0%

2,3-Diaminopyridine (452-58-4) + 1,1,1,5,5,5-hexafluoroacetylacetone (1522-22-1) → 2-Trifluoromethyl-3H-imidazo<4,5-b>pyridine (13797-63-2)

Guidance literature:

With iron(III) trifluoromethanesulfonate; In N,N-dimethyl-formamide; at 80 ℃; for 24h;

DOI:10.1016/j.tetlet.2016.06.086

upstream raw materials:

2,3-Diaminopyridine

trifluoroacetic acid

1,1,1,5,5,5-hexafluoroacetylacetone

Downstream raw materials:

C₁₃H₇F₃N₄O₂

4-[(6-chloro-3-pyridyl)methyl]-2-(trifluoromethyl)imidazo[4,5-b]pyridine