methyl 13α-<<2(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>amino>-3,3,14,14-tetramethyl-6,9,12-trioxo-7β-(phenylmethyl)-1,2-dithia-5,8,11-triazacyclotetradecane-(4R)-4α-carboxylate

Base Information

Chemical Name:methyl 13α-<<2(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>amino>-3,3,14,14-tetramethyl-6,9,12-trioxo-7β-(phenylmethyl)-1,2-dithia-5,8,11-triazacyclotetradecane-(4R)-4α-carboxylate
CAS No.:142929-47-3
Molecular Formula:C₃₈H₅₃N₅O₉S₂
Molecular Weight:787.999
Hs Code.:

methyl 13α-<<2(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>amino>-3,3,14,14-tetramethyl-6,9,12-trioxo-7β-(phenylmethyl)-1,2-dithia-5,8,11-triazacyclotetradecane-(4R)-4α-carboxylate

Synonyms:methyl 13α-<<2(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>amino>-3,3,14,14-tetramethyl-6,9,12-trioxo-7β-(phenylmethyl)-1,2-dithia-5,8,11-triazacyclotetradecane-(4R)-4α-carboxylate

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Chemical Property of methyl 13α-<<2(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>amino>-3,3,14,14-tetramethyl-6,9,12-trioxo-7β-(phenylmethyl)-1,2-dithia-5,8,11-triazacyclotetradecane-(4R)-4α-carboxylate

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Technology Process of methyl 13α-<<2(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>amino>-3,3,14,14-tetramethyl-6,9,12-trioxo-7β-(phenylmethyl)-1,2-dithia-5,8,11-triazacyclotetradecane-(4R)-4α-carboxylate

There total 12 articles about methyl 13α-<<2(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>amino>-3,3,14,14-tetramethyl-6,9,12-trioxo-7β-(phenylmethyl)-1,2-dithia-5,8,11-triazacyclotetradecane-(4R)-4α-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₃₁NO₇

: 749180-44-7
(4S,7S,13S)-13-Amino-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triaza-cyclotetradecane-4-carboxylic acid methyl ester

: 142929-47-3
methyl 13α-<<2(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>amino>-3,3,14,14-tetramethyl-6,9,12-trioxo-7β-(phenylmethyl)-1,2-dithia-5,8,11-triazacyclotetradecane-(4R)-4α-carboxylate

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide; at -23 - 20 ℃; for 16h; Yield given;
DOI:10.1021/jm00094a002

Reference yield:

: 29913-83-5
D-penicillamine methyl ester

: 142929-47-3
methyl 13α-<<2(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>amino>-3,3,14,14-tetramethyl-6,9,12-trioxo-7β-(phenylmethyl)-1,2-dithia-5,8,11-triazacyclotetradecane-(4R)-4α-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1-methylmorpholine (NMM) / tetrahydrofuran; dimethylformamide / 16 h / -23 - 20 °C

2: 72 percent / I₂ / aq. acetic acid / 0.33 h

3: HCl / tetrahydrofuran; dioxane / 0.25 h / Ambient temperature

4: 1-methylmorpholine (NMM) / tetrahydrofuran; dimethylformamide / 16 h / -23 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; iodine; In tetrahydrofuran; 1,4-dioxane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00094a002

Reference yield:

: 106624-70-8,41889-06-9
methyl (2S)-2-[[2-(t-butoxycarbonylamino)acetyl]amino]-3-phenylpropanoate

: 142929-47-3
methyl 13α-<<2(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>amino>-3,3,14,14-tetramethyl-6,9,12-trioxo-7β-(phenylmethyl)-1,2-dithia-5,8,11-triazacyclotetradecane-(4R)-4α-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: HCl(gas.) / CH₂Cl₂; dioxane / 0.25 h / Ambient temperature

2: 1-methylmorpholine (NMM) / tetrahydrofuran; dimethylformamide / 16 h / -23 - 20 °C

3: 90 percent / aq. LiOH / tetrahydrofuran / 0.5 h / 0 °C

4: 1-methylmorpholine (NMM) / tetrahydrofuran / 0.75 h / -23 °C

5: 1-methylmorpholine (NMM) / tetrahydrofuran; dimethylformamide / 16 h / -23 - 20 °C

6: 72 percent / I₂ / aq. acetic acid / 0.33 h

7: HCl / tetrahydrofuran; dioxane / 0.25 h / Ambient temperature

8: 1-methylmorpholine (NMM) / tetrahydrofuran; dimethylformamide / 16 h / -23 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide; iodine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00094a002