Z-Val-Asp(β-tert-butyl)vinyl methylsulfone

Base Information

Chemical Name:Z-Val-Asp(β-tert-butyl)vinyl methylsulfone
CAS No.:1246261-58-4
Molecular Formula:C₂₃H₃₄N₂O₇S
Molecular Weight:482.598
Hs Code.:

Synonyms:Z-Val-Asp(β-tert-butyl)vinyl methylsulfone

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Chemical Property of Z-Val-Asp(β-tert-butyl)vinyl methylsulfone

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Technology Process of Z-Val-Asp(β-tert-butyl)vinyl methylsulfone

There total 6 articles about Z-Val-Asp(β-tert-butyl)vinyl methylsulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 40137-11-9
diethyl methylsulfonylmethylphosphonate

: 1246261-48-2
C₂₁H₃₀N₂O₆

: 1246261-58-4
Z-Val-Asp(β-tert-butyl)vinyl methylsulfone

Guidance literature:: diethyl methylsulfonylmethylphosphonate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;

C₂₁H₃₀N₂O₆; In tetrahydrofuran; mineral oil; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2010.05.039

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: Asp(β-tert-butyl)vinyl methylsulfone tosyl salt

: 1246261-58-4
Z-Val-Asp(β-tert-butyl)vinyl methylsulfone

Guidance literature:: (S)-N-(benzyloxycarbonyl)valine; With 4-methyl-morpholine; isobutyl chloroformate; In dichloromethane; N,N-dimethyl-formamide; at -20 - -15 ℃; for 0.166667h;

Asp(β-tert-butyl)vinyl methylsulfone tosyl salt; With 4-methyl-morpholine; In dichloromethane; N,N-dimethyl-formamide; at -20 - -15 ℃; for 0.583333h;

Reference yield:

: 153248-79-4
N-α-(tert-butoxycarbonyl)-β-tert-butyl-L-aspartal

: 1246261-58-4
Z-Val-Asp(β-tert-butyl)vinyl methylsulfone

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

1.2: 1.17 h / 0 - 20 °C

2.1: dichloromethane; diethyl ether / 15 h / 20 °C

3.1: isobutyl chloroformate; 4-methyl-morpholine / N,N-dimethyl-formamide; dichloromethane / 0.17 h / -20 - -15 °C

3.2: 0.58 h / -20 - -15 °C

With 4-methyl-morpholine; sodium hydride; isobutyl chloroformate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;