5-chloro-1-{4-[2-(3,4-difluoro-phenyl)-ethyl]-piperazin-1-yl}-9-methyl-9H-2,4,6,9-tetraaza-fluorene

Base Information

Chemical Name:5-chloro-1-{4-[2-(3,4-difluoro-phenyl)-ethyl]-piperazin-1-yl}-9-methyl-9H-2,4,6,9-tetraaza-fluorene
CAS No.:676601-77-7
Molecular Formula:C₂₂H₂₁ClF₂N₆
Molecular Weight:442.899
Hs Code.:

Synonyms:5-chloro-1-{4-[2-(3,4-difluoro-phenyl)-ethyl]-piperazin-1-yl}-9-methyl-9H-2,4,6,9-tetraaza-fluorene

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Chemical Property of 5-chloro-1-{4-[2-(3,4-difluoro-phenyl)-ethyl]-piperazin-1-yl}-9-methyl-9H-2,4,6,9-tetraaza-fluorene

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Technology Process of 5-chloro-1-{4-[2-(3,4-difluoro-phenyl)-ethyl]-piperazin-1-yl}-9-methyl-9H-2,4,6,9-tetraaza-fluorene

There total 8 articles about 5-chloro-1-{4-[2-(3,4-difluoro-phenyl)-ethyl]-piperazin-1-yl}-9-methyl-9H-2,4,6,9-tetraaza-fluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 676601-75-5
1,5-dichloro-9-methyl-9H-2,4,6,9-tetraazafluorene

: 179534-91-9
1-[2-(3,4-difluorophenyl)ethyl]piperazine

: 676601-77-7
5-chloro-1-{4-[2-(3,4-difluoro-phenyl)-ethyl]-piperazin-1-yl}-9-methyl-9H-2,4,6,9-tetraaza-fluorene

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 20h;
DOI:10.1021/jm0310129

Reference yield:

: 676601-68-6
2-chloro-4-methylaminopyridine-3-nitrile

: 676601-77-7
5-chloro-1-{4-[2-(3,4-difluoro-phenyl)-ethyl]-piperazin-1-yl}-9-methyl-9H-2,4,6,9-tetraaza-fluorene

Guidance literature:: Multi-step reaction with 7 steps

1: 61 percent / NaH / dimethylformamide / 40 °C

2: 96 percent / H₂ / Pd/C / ethanol / 24 h / 20 °C / atmospheric pressure

3: dimethylformamide / 100 °C

4: NH₃ / ethanol / 100 °C

5: 99 percent / m-chlorobenzoic acid / CHCl₃ / 16 h / 20 °C

6: 54 percent / Et₃N*HCl; POCl₃ / 2 h / Heating

7: 79 percent / Et₃N / dimethylformamide / 20 h / 50 °C

With ammonia; hydrogen; triethylamine hydrochloride; sodium hydride; triethylamine; 3-chlorobenzoate; trichlorophosphate; palladium on activated charcoal; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm0310129

Reference yield:

: 676601-69-7
3-amino-4-chloro-1-methyl-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid ethyl ester

: 676601-77-7
5-chloro-1-{4-[2-(3,4-difluoro-phenyl)-ethyl]-piperazin-1-yl}-9-methyl-9H-2,4,6,9-tetraaza-fluorene

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / H₂ / Pd/C / ethanol / 24 h / 20 °C / atmospheric pressure

2: dimethylformamide / 100 °C

3: NH₃ / ethanol / 100 °C

4: 99 percent / m-chlorobenzoic acid / CHCl₃ / 16 h / 20 °C

5: 54 percent / Et₃N*HCl; POCl₃ / 2 h / Heating

6: 79 percent / Et₃N / dimethylformamide / 20 h / 50 °C

With ammonia; hydrogen; triethylamine hydrochloride; triethylamine; 3-chlorobenzoate; trichlorophosphate; palladium on activated charcoal; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm0310129