5-formyl-5'-[(E)-(4-N,N-dimethylaminobenzylidene)methyl]-2,2'-bithiophene

Base Information

Chemical Name:5-formyl-5'-[(E)-(4-N,N-dimethylaminobenzylidene)methyl]-2,2'-bithiophene
CAS No.:336608-02-7
Molecular Formula:C₁₉H₁₇NOS₂
Molecular Weight:339.482
Hs Code.:

Synonyms:5-formyl-5'-[(E)-(4-N,N-dimethylaminobenzylidene)methyl]-2,2'-bithiophene

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Chemical Property of 5-formyl-5'-[(E)-(4-N,N-dimethylaminobenzylidene)methyl]-2,2'-bithiophene

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Technology Process of 5-formyl-5'-[(E)-(4-N,N-dimethylaminobenzylidene)methyl]-2,2'-bithiophene

There total 5 articles about 5-formyl-5'-[(E)-(4-N,N-dimethylaminobenzylidene)methyl]-2,2'-bithiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 336607-97-7
5-[(E)-(4-N,N-dimethylaminobenzylidene)methyl]-2,2'-bithiophene

: 336608-02-7
5-formyl-5'-[(E)-(4-N,N-dimethylaminobenzylidene)methyl]-2,2'-bithiophene

Guidance literature:: With trichlorophosphate;
DOI:10.1016/S0040-4039(00)02317-0

Reference yield:

: 3779-27-9
2,2'-bithiophene-5-carboxaldehyde

: 336608-02-7
5-formyl-5'-[(E)-(4-N,N-dimethylaminobenzylidene)methyl]-2,2'-bithiophene

Guidance literature:: Multi-step reaction with 2 steps

1.1: t-BuOK / tetrahydrofuran; acetonitrile / 0.25 h / 0 °C

1.2: 93 percent / tetrahydrofuran; acetonitrile / 3 h / -70 - 20 °C

2.1: 60 percent / POCl₃ / 1,2-dichloro-ethane / 18 h / Heating

With potassium tert-butylate; trichlorophosphate; In tetrahydrofuran; 1,2-dichloro-ethane; acetonitrile; 1.2: Wittig reaction / 2.1: Vilsmeier reaction;
DOI:10.1021/jo010713f

Reference yield:

: 492-97-7
2,2'-Bithiophene

: 336608-02-7
5-formyl-5'-[(E)-(4-N,N-dimethylaminobenzylidene)methyl]-2,2'-bithiophene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 94 percent / POCl₃ / 1,2-dichloro-ethane / 2 h / Heating

2.1: t-BuOK / tetrahydrofuran; acetonitrile / 0.25 h / 0 °C

2.2: 93 percent / tetrahydrofuran; acetonitrile / 3 h / -70 - 20 °C

3.1: 60 percent / POCl₃ / 1,2-dichloro-ethane / 18 h / Heating

With potassium tert-butylate; trichlorophosphate; In tetrahydrofuran; 1,2-dichloro-ethane; acetonitrile; 1.1: Vilsmeier reaction / 2.2: Wittig reaction / 3.1: Vilsmeier reaction;
DOI:10.1021/jo010713f