diethyl 1-phenyl-3-(4-(2-fluoroethoxy)phenyl)-4,5-dihydro-1H-pyrazole-4,5-dicarboxylate

Base Information

Chemical Name:diethyl 1-phenyl-3-(4-(2-fluoroethoxy)phenyl)-4,5-dihydro-1H-pyrazole-4,5-dicarboxylate
CAS No.:1338070-34-0
Molecular Formula:C₂₃H₂₅FN₂O₅
Molecular Weight:428.46
Hs Code.:

Synonyms:diethyl 1-phenyl-3-(4-(2-fluoroethoxy)phenyl)-4,5-dihydro-1H-pyrazole-4,5-dicarboxylate

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Chemical Property of diethyl 1-phenyl-3-(4-(2-fluoroethoxy)phenyl)-4,5-dihydro-1H-pyrazole-4,5-dicarboxylate

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Technology Process of diethyl 1-phenyl-3-(4-(2-fluoroethoxy)phenyl)-4,5-dihydro-1H-pyrazole-4,5-dicarboxylate

There total 6 articles about diethyl 1-phenyl-3-(4-(2-fluoroethoxy)phenyl)-4,5-dihydro-1H-pyrazole-4,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1319719-77-1
5-(4-(2-fluoroethoxy)phenyl)-2-phenyl-2H-tetrazole

: 623-91-6
diethyl Fumarate

: 1338070-34-0
diethyl 1-phenyl-3-(4-(2-fluoroethoxy)phenyl)-4,5-dihydro-1H-pyrazole-4,5-dicarboxylate

Guidance literature:: In ethyl acetate; at 20 ℃; for 4h; UV-irradiation;
DOI:10.1016/j.tet.2011.05.122

Reference yield:

: C₁₅H₁₆N₂O₄S

: 1338070-34-0
diethyl 1-phenyl-3-(4-(2-fluoroethoxy)phenyl)-4,5-dihydro-1H-pyrazole-4,5-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / ethanol; water / -20 - -10 °C

1.2: 3.33 h / -20 - 20 °C

2.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

3.1: cesium fluoride / dimethyl sulfoxide / 18 h / 80 °C

4.1: ethyl acetate / 4 h / 20 °C / UV-irradiation

With hydrogenchloride; triethylamine; cesium fluoride; sodium nitrite; In ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/j.tet.2011.05.122

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1338070-34-0
diethyl 1-phenyl-3-(4-(2-fluoroethoxy)phenyl)-4,5-dihydro-1H-pyrazole-4,5-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water; butan-1-ol / Reflux

2.1: ethanol / 1 h / 20 °C

3.1: hydrogenchloride; sodium nitrite / ethanol; water / -20 - -10 °C

3.2: 3.33 h / -20 - 20 °C

4.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

5.1: cesium fluoride / dimethyl sulfoxide / 18 h / 80 °C

6.1: ethyl acetate / 4 h / 20 °C / UV-irradiation

With hydrogenchloride; triethylamine; cesium fluoride; sodium hydroxide; sodium nitrite; In ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; butan-1-ol;
DOI:10.1016/j.tet.2011.05.122