[({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)methyl]phosphonic acid trifluoroacetate

Base Information

Chemical Name:[({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)methyl]phosphonic acid trifluoroacetate
CAS No.:1345983-22-3
Molecular Formula:C₂HF₃O₂*C₂₄H₃₅N₂O₆PS
Molecular Weight:624.615
Hs Code.:

[({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)methyl]phosphonic acid trifluoroacetate

Synonyms:[({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)methyl]phosphonic acid trifluoroacetate

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Chemical Property of [({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)methyl]phosphonic acid trifluoroacetate

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Technology Process of [({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)methyl]phosphonic acid trifluoroacetate

There total 2 articles about [({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)methyl]phosphonic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.4%

: diethyl [({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)methyl]phosphonate

: 76-05-1
trifluoroacetic acid

: 1345983-22-3
[({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)methyl]phosphonic acid trifluoroacetate

Guidance literature:: diethyl [({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)methyl]phosphonate; With trimethylsilyl bromide; In dichloromethane; at 23 ℃; for 18h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1345983-52-9
{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amine

: 1345983-22-3
[({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)methyl]phosphonic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 88 h / 75 °C

2: trimethylsilyl bromide / dichloromethane / 18 h / 23 °C

With trimethylsilyl bromide; In tetrahydrofuran; dichloromethane;