2-chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid(2,4-dimethoxy-phenyl)-amide

Base Information

• Chemical Name: 2-chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid(2,4-dimethoxy-phenyl)-amide
• CAS No.: 1356017-12-3
• Molecular Formula: C₁₅H₁₂ClN₃O₃S
• Molecular Weight: 349.798
• Mol file: 1356017-12-3.mol

Synonyms:2-chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid(2,4-dimethoxy-phenyl)-amide

Chemical Property of 2-chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid(2,4-dimethoxy-phenyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid(2,4-dimethoxy-phenyl)-amide

There total 6 articles about 2-chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid(2,4-dimethoxy-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid (1356016-36-8) + 2,4-Dimethoxyaniline (2735-04-8,161687-55-4) → 2-chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid(2,4-dimethoxy-phenyl)-amide (1356017-12-3)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester (85006-31-1) → 2-chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid(2,4-dimethoxy-phenyl)-amide (1356017-12-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: acetonitrile / 0.25 h

1.2: 0.25 h / 70 °C

2.1: trichlorophosphate / 0.25 h / 180 °C / microwave

3.1: hydrogen; sodium acetate / 20% palladium hydroxide-activated charcoal / ethyl acetate; isopropyl alcohol / 2585.81 Torr

4.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 1 h / Reflux

4.2: 0.5 h / 100 °C

5.1: aminosulfonic acid; potassium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol; tetrahydrofuran / 1 h

6.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

With sodium chlorite; potassium dihydrogenphosphate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); aminosulfonic acid; hydrogen; sodium acetate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; tetrachloromethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; tert-butyl alcohol;

Reference yield:

2,4-dichloro-7-methyl-thieno[3,2-d]pyrimidine (35265-83-9) → 2-chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid(2,4-dimethoxy-phenyl)-amide (1356017-12-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogen; sodium acetate / 20% palladium hydroxide-activated charcoal / ethyl acetate; isopropyl alcohol / 2585.81 Torr

2.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 1 h / Reflux

2.2: 0.5 h / 100 °C

3.1: aminosulfonic acid; potassium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol; tetrahydrofuran / 1 h

4.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

With sodium chlorite; potassium dihydrogenphosphate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); aminosulfonic acid; hydrogen; sodium acetate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; tetrachloromethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol;

upstream raw materials:

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

7-methylthieno<3,2-d>pyrimidine-2,4-dione

2,4-dichloro-7-methyl-thieno[3,2-d]pyrimidine

2-chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid