N-de-tert-butoxycarbonyl-7,10-di(2,2,2-trichloroethyloxycarbonyl)-2-debenzoyl-2-(m-fluorobenzoyl)docetaxel

Base Information

• Chemical Name: N-de-tert-butoxycarbonyl-7,10-di(2,2,2-trichloroethyloxycarbonyl)-2-debenzoyl-2-(m-fluorobenzoyl)docetaxel
• CAS No.: 912271-98-8
• Molecular Formula: C₄₄H₄₆Cl₆FNO₁₆
• Molecular Weight: 1076.56

Synonyms:N-de-tert-butoxycarbonyl-7,10-di(2,2,2-trichloroethyloxycarbonyl)-2-debenzoyl-2-(m-fluorobenzoyl)docetaxel

Chemical Property of N-de-tert-butoxycarbonyl-7,10-di(2,2,2-trichloroethyloxycarbonyl)-2-debenzoyl-2-(m-fluorobenzoyl)docetaxel

Chemical Property:

Purity/Quality:

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• Pictogram(s):  
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Technology Process of N-de-tert-butoxycarbonyl-7,10-di(2,2,2-trichloroethyloxycarbonyl)-2-debenzoyl-2-(m-fluorobenzoyl)docetaxel

There total 1 articles about N-de-tert-butoxycarbonyl-7,10-di(2,2,2-trichloroethyloxycarbonyl)-2-debenzoyl-2-(m-fluorobenzoyl)docetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

7,10-di(2,2,2-trichloroethyloxycarbonyl)-2-debenzoyl-2-(m-fluorobenzoyl)-10-deacetylbaccatin III-13-O-[(4S,5R)-4-phenyl-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidine-5-carboxylate] (912271-97-7) → N-de-tert-butoxycarbonyl-7,10-di(2,2,2-trichloroethyloxycarbonyl)-2-debenzoyl-2-(m-fluorobenzoyl)docetaxel (912271-98-8)

Guidance literature:

With formic acid; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2008.04.004

Reference yield: 75.0%

C5H7ClF2O2 (912272-01-6) + N-de-tert-butoxycarbonyl-7,10-di(2,2,2-trichloroethyloxycarbonyl)-2-debenzoyl-2-(m-fluorobenzoyl)docetaxel (912271-98-8) → N-de-tert-butoxycarbonyl-N-[2-(1,1-difluoro-2-methyl)-propyloxycarbonyl]-7,10-di(2,2,2-trichloroethyloxycarbonyl)-2-debenzoyl-2-(m-fluorobenzoyl)docetaxel (912272-04-9)

Guidance literature:

In water; ethyl acetate; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2008.04.004

Reference yield: 20.0%

C5H8ClFO2 (912272-00-5) + N-de-tert-butoxycarbonyl-7,10-di(2,2,2-trichloroethyloxycarbonyl)-2-debenzoyl-2-(m-fluorobenzoyl)docetaxel (912271-98-8) → N-de-tert-butoxycarbonyl-N-[2-(1-fluoro-2-methyl)-propyloxycarbonyl]-7,10-di(2,2,2-trichloroethyloxycarbonyl)-2-debenzoyl-2-(m-fluorobenzoyl)docetaxel (912272-03-8)

Guidance literature:

In water; ethyl acetate; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2008.04.004

upstream raw materials:

7,10-di(2,2,2-trichloroethyloxycarbonyl)-2-debenzoyl-2-(m-fluorobenzoyl)-10-deacetylbaccatin III-13-O-[(4S,5R)-4-phenyl-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidine-5-carboxylate]

Downstream raw materials:

N-de-tert-butoxycarbonyl-N-[2-(1-fluoro-2-methyl)-propyloxycarbonyl]-7,10-di(2,2,2-trichloroethyloxycarbonyl)-2-debenzoyl-2-(m-fluorobenzoyl)docetaxel

N-de-tert-butoxycarbonyl-N-[2-(1,1-difluoro-2-methyl)-propyloxycarbonyl]-7,10-di(2,2,2-trichloroethyloxycarbonyl)-2-debenzoyl-2-(m-fluorobenzoyl)docetaxel

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