3-benzyl-2-[2-(1-chloro-ethyl)-4-fluoro-phenoxy]-6-(4-phenyl-[1,2,3]triazol-1-yl)-quinoline

Base Information

• Chemical Name: 3-benzyl-2-[2-(1-chloro-ethyl)-4-fluoro-phenoxy]-6-(4-phenyl-[1,2,3]triazol-1-yl)-quinoline
• CAS No.: 1173292-08-4
• Molecular Formula: C₃₂H₂₄ClFN₄O
• Molecular Weight: 535.02

Synonyms:3-benzyl-2-[2-(1-chloro-ethyl)-4-fluoro-phenoxy]-6-(4-phenyl-[1,2,3]triazol-1-yl)-quinoline

Chemical Property of 3-benzyl-2-[2-(1-chloro-ethyl)-4-fluoro-phenoxy]-6-(4-phenyl-[1,2,3]triazol-1-yl)-quinoline

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Technology Process of 3-benzyl-2-[2-(1-chloro-ethyl)-4-fluoro-phenoxy]-6-(4-phenyl-[1,2,3]triazol-1-yl)-quinoline

There total 1 articles about 3-benzyl-2-[2-(1-chloro-ethyl)-4-fluoro-phenoxy]-6-(4-phenyl-[1,2,3]triazol-1-yl)-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1-{2-[3-benzyl-6-(4-phenyl-[1,2,3]triazol-1-yl)-quinolin-2-yloxy]-5-fluoro-phenyl}-ethanol (1173290-11-3) → 3-benzyl-2-[2-(1-chloro-ethyl)-4-fluoro-phenoxy]-6-(4-phenyl-[1,2,3]triazol-1-yl)-quinoline (1173292-08-4)

Guidance literature:

With thionyl chloride; In acetonitrile; at 0 - 20 ℃; for 1h;

Reference yield: 60.0%

1H-imidazole (288-32-4) + 3-benzyl-2-[2-(1-chloro-ethyl)-4-fluoro-phenoxy]-6-(4-phenyl-[1,2,3]triazol-1-yl)-quinoline (1173292-08-4) → 3-benzyl-2-[4-fluoro-2-(1-imidazol-1-yl-ethyl)-phenoxy]-6-(4-phenyl-[1,2,3]triazol-1-yl)-quinoline (1173289-94-5)

Guidance literature:

With triethylamine; In acetonitrile; for 12h; Heating / reflux;

Reference yield: 26.0%

piperidine (110-89-4) + 3-benzyl-2-[2-(1-chloro-ethyl)-4-fluoro-phenoxy]-6-(4-phenyl-[1,2,3]triazol-1-yl)-quinoline (1173292-08-4) → 3-benzyl-2-[4-fluoro-2-(1-piperidin-1-yl-ethyl)-phenoxy]-6-(4-phenyl-[1,2,3]triazol-1-yl)-quinoline (1173290-12-4)

Guidance literature:

With triethylamine; In acetonitrile; for 12h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmc.2009.04.069

upstream raw materials:

1-{2-[3-benzyl-6-(4-phenyl-[1,2,3]triazol-1-yl)-quinolin-2-yloxy]-5-fluoro-phenyl}-ethanol

Downstream raw materials:

3-benzyl-2-[4-fluoro-2-(1-imidazol-1-yl-ethyl)-phenoxy]-6-(4-phenyl-[1,2,3]triazol-1-yl)-quinoline

3-benzyl-2-[4-fluoro-2-(1-piperidin-1-yl-ethyl)-phenoxy]-6-(4-phenyl-[1,2,3]triazol-1-yl)-quinoline

3-benzyl-2-{4-fluoro-2-[1-(4-pyridin-2-yl-piperazin-1-yl)-ethyl]-phenoxy}-6-(4-phenyl-[1,2,3]triazol-1-yl)-quinoline

3-benzyl-2-(4-fluoro-2-{1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethyl}-phenoxy)-6-(4-phenyl-[1,2,3]triazol-1-yl)-quinoline

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