3-butyl-3-hydroxy-2-(phenylmethylene)-4-propylcyclopentanecarbonitrile

Base Information

• Chemical Name: 3-butyl-3-hydroxy-2-(phenylmethylene)-4-propylcyclopentanecarbonitrile
• CAS No.: 99142-54-8
• Molecular Formula: C₂₀H₂₇NO
• Molecular Weight: 297.44
• Mol file: 99142-54-8.mol

Synonyms:3-butyl-3-hydroxy-2-(phenylmethylene)-4-propylcyclopentanecarbonitrile

Chemical Property of 3-butyl-3-hydroxy-2-(phenylmethylene)-4-propylcyclopentanecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-butyl-3-hydroxy-2-(phenylmethylene)-4-propylcyclopentanecarbonitrile

There total 2 articles about 3-butyl-3-hydroxy-2-(phenylmethylene)-4-propylcyclopentanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

5-hydroxy-5-(phenylethynyl)-2-(phenylseleno)-4-propylnonanenitrile (99142-51-5) → 3-butyl-3-hydroxy-2-(phenylmethylene)-4-propylcyclopentanecarbonitrile (99142-54-8)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); triphenylstannane; In benzene; for 2h; Heating;

DOI:10.1021/jo00231a021 DOI:10.1039/C39850000941

Reference yield:

5-oxo-2-(phenylseleno)-4-propylnonanenitrile (99142-47-9) → 3-butyl-3-hydroxy-2-(phenylmethylene)-4-propylcyclopentanecarbonitrile (99142-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / tetrahydrofuran / 1 h / -78 °C

2: 79 percent / triphenyltin hydride, AIBN / benzene / 2 h / Heating

With 2,2'-azobis(isobutyronitrile); triphenylstannane; In tetrahydrofuran; benzene;

DOI:10.1039/C39850000941

upstream raw materials:

5-hydroxy-5-(phenylethynyl)-2-(phenylseleno)-4-propylnonanenitrile

5-oxo-2-(phenylseleno)-4-propylnonanenitrile