(7R,8R,8aS)-8-Benzyloxy-6-[1-iodo-pent-(Z)-ylidene]-8-methyl-octahydro-indolizin-7-ol

Base Information

Chemical Name:(7R,8R,8aS)-8-Benzyloxy-6-[1-iodo-pent-(Z)-ylidene]-8-methyl-octahydro-indolizin-7-ol
CAS No.:182000-74-4
Molecular Formula:C₂₁H₃₀INO₂
Molecular Weight:455.379
Hs Code.:

Synonyms:(7R,8R,8aS)-8-Benzyloxy-6-[1-iodo-pent-(Z)-ylidene]-8-methyl-octahydro-indolizin-7-ol

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Chemical Property of (7R,8R,8aS)-8-Benzyloxy-6-[1-iodo-pent-(Z)-ylidene]-8-methyl-octahydro-indolizin-7-ol

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Technology Process of (7R,8R,8aS)-8-Benzyloxy-6-[1-iodo-pent-(Z)-ylidene]-8-methyl-octahydro-indolizin-7-ol

There total 12 articles about (7R,8R,8aS)-8-Benzyloxy-6-[1-iodo-pent-(Z)-ylidene]-8-methyl-octahydro-indolizin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 182000-81-3
(3R,4R,4aS)-4-Benzyloxy-3-hex-1-ynyl-4-methyl-hexahydro-pyrrolo[1,2-c][1,3]oxazine

: 182000-74-4
(7R,8R,8aS)-8-Benzyloxy-6-[1-iodo-pent-(Z)-ylidene]-8-methyl-octahydro-indolizin-7-ol

Guidance literature:: With formaldehyd; camphor-10-sulfonic acid; sodium iodide; at 100 ℃;
DOI:10.1021/ja961640y

Reference yield: 36.0%

: 182000-60-8
[(S)-2-((1R,2R)-1-Benzyloxy-2-hydroxy-1-methyl-oct-3-ynyl)-pyrrolidin-1-yl]-acetonitrile

: 182000-74-4
(7R,8R,8aS)-8-Benzyloxy-6-[1-iodo-pent-(Z)-ylidene]-8-methyl-octahydro-indolizin-7-ol

Guidance literature:: With formaldehyd; camphor-10-sulfonic acid; sodium iodide; at 100 ℃;
DOI:10.1021/ja961640y

Reference yield:

: 123190-88-5
(R)-2-(S)-Pyrrolidin-2-yl-1-(2-trimethylsilanyl-ethoxymethoxy)-propan-2-ol

: 182000-74-4
(7R,8R,8aS)-8-Benzyloxy-6-[1-iodo-pent-(Z)-ylidene]-8-methyl-octahydro-indolizin-7-ol

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / tetrahydrofuran / 2 h / Ambient temperature

2: 91 percent / KH / tetrahydrofuran / 0.5 h / Heating

3: 78 percent / aq. LiBF₄ / acetonitrile / 2 h / 70 °C

4: 77 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 0.5 h / -78 °C

5: 1.) ClTi(O-i-Pr)3 / 1.) THF, -50 deg C

6: 76 percent / AgNO₃ / ethanol / Ambient temperature

7: 71 percent / NaI, aq. CH₂O, camphorsulphonic acid / 100 °C

With triisopropoxytitanium(IV) chloride; lithium tetrafluoroborate; formaldehyd; oxalyl dichloride; camphor-10-sulfonic acid; potassium hydride; silver nitrate; dimethyl sulfoxide; triethylamine; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/ja961640y