7-(2-(2,5-difluorophenyl)-5-methylpyridin-4-ylamino)-N-ethyl-1H-pyrazolo[4,3-b]pyridine-1-carboxamide

Base Information

Chemical Name:7-(2-(2,5-difluorophenyl)-5-methylpyridin-4-ylamino)-N-ethyl-1H-pyrazolo[4,3-b]pyridine-1-carboxamide
CAS No.:1350647-08-3
Molecular Formula:C₂₁H₁₈F₂N₆O
Molecular Weight:408.41
Hs Code.:

Synonyms:7-(2-(2,5-difluorophenyl)-5-methylpyridin-4-ylamino)-N-ethyl-1H-pyrazolo[4,3-b]pyridine-1-carboxamide

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Chemical Property of 7-(2-(2,5-difluorophenyl)-5-methylpyridin-4-ylamino)-N-ethyl-1H-pyrazolo[4,3-b]pyridine-1-carboxamide

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Technology Process of 7-(2-(2,5-difluorophenyl)-5-methylpyridin-4-ylamino)-N-ethyl-1H-pyrazolo[4,3-b]pyridine-1-carboxamide

There total 9 articles about 7-(2-(2,5-difluorophenyl)-5-methylpyridin-4-ylamino)-N-ethyl-1H-pyrazolo[4,3-b]pyridine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350647-07-2,1350649-41-0
N-(2-(2,5-difluorophenyl)-5-methylpyridin-4-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine

: 109-90-0
ethyl isocyanate

: 1350647-08-3
7-(2-(2,5-difluorophenyl)-5-methylpyridin-4-ylamino)-N-ethyl-1H-pyrazolo[4,3-b]pyridine-1-carboxamide

Guidance literature:: With pyridine; In acetonitrile; at 75 ℃; for 2h;

Reference yield:

: 97509-75-6
3-fluoropicolinonitrile

: 1350647-08-3
7-(2-(2,5-difluorophenyl)-5-methylpyridin-4-ylamino)-N-ethyl-1H-pyrazolo[4,3-b]pyridine-1-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.42 h / -78 °C

1.2: 0.67 h / -78 °C

2.1: hydrazine hydrate / butan-1-ol / 2 h / 105 °C

3.1: sodium nitrite; acetic acid / water / 25 h / 0 - 20 °C

3.2: 3 h / 80 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

4.2: 0.5 h / Cooling with ice

5.1: sodium t-butanolate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / palladium diacetate / toluene / 100 °C

5.2: 3 h / 70 °C

6.1: pyridine / acetonitrile / 2 h / 75 °C

With pyridine; n-butyllithium; sodium hydride; hydrazine hydrate; acetic acid; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; diisopropylamine; sodium t-butanolate; sodium nitrite; palladium diacetate; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; toluene; acetonitrile; butan-1-ol;

Reference yield:

: 669066-35-7
3-fluoro-4-iodo-2-pyridinecarbonitrile

: 1350647-08-3
7-(2-(2,5-difluorophenyl)-5-methylpyridin-4-ylamino)-N-ethyl-1H-pyrazolo[4,3-b]pyridine-1-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / butan-1-ol / 2 h / 105 °C

2.1: sodium nitrite; acetic acid / water / 25 h / 0 - 20 °C

2.2: 3 h / 80 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

3.2: 0.5 h / Cooling with ice

4.1: sodium t-butanolate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / palladium diacetate / toluene / 100 °C

4.2: 3 h / 70 °C

5.1: pyridine / acetonitrile / 2 h / 75 °C

With pyridine; sodium hydride; hydrazine hydrate; acetic acid; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate; sodium nitrite; palladium diacetate; In water; N,N-dimethyl-formamide; toluene; acetonitrile; butan-1-ol;