3-[[4-[4-[(2-aminoethyl)amino]phenyl]-3,5-dimethyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one

Base Information

Chemical Name:3-[[4-[4-[(2-aminoethyl)amino]phenyl]-3,5-dimethyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one
CAS No.:1312226-42-8
Molecular Formula:C₂₃H₂₄N₄O
Molecular Weight:372.47
Hs Code.:

Synonyms:3-[[4-[4-[(2-aminoethyl)amino]phenyl]-3,5-dimethyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one

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Chemical Property of 3-[[4-[4-[(2-aminoethyl)amino]phenyl]-3,5-dimethyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one

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Technology Process of 3-[[4-[4-[(2-aminoethyl)amino]phenyl]-3,5-dimethyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one

There total 6 articles about 3-[[4-[4-[(2-aminoethyl)amino]phenyl]-3,5-dimethyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312226-40-6
3-[[4-(4-aminophenyl)-3,5-dimethyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one

: 2576-47-8
2-bromoethylamine hydrobromide

: 1312226-42-8
3-[[4-[4-[(2-aminoethyl)amino]phenyl]-3,5-dimethyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one

Guidance literature:: With triethylamine; In isopropyl alcohol; for 24h; Reflux;
DOI:10.1016/j.bmc.2011.04.008

Reference yield:

: 59-48-3
2-oxoindole

: 1312226-42-8
3-[[4-[4-[(2-aminoethyl)amino]phenyl]-3,5-dimethyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: piperidine / methanol / 65 °C

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 1 h / 105 °C

4: 10% palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C

5: triethylamine / isopropyl alcohol / 24 h / Reflux

With piperidine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; 10% palladium on activated charcoal; hydrogen; potassium carbonate; triethylamine; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; water; isopropyl alcohol; 3: Suzuki coupling;
DOI:10.1016/j.bmc.2011.04.008

Reference yield:

: 2199-58-8
3,5-dimethylpyrrole-2-carbaldehyde

: 1312226-42-8
3-[[4-[4-[(2-aminoethyl)amino]phenyl]-3,5-dimethyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: piperidine / methanol / 65 °C

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 1 h / 105 °C

4: 10% palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C

5: triethylamine / isopropyl alcohol / 24 h / Reflux

With piperidine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; 10% palladium on activated charcoal; hydrogen; potassium carbonate; triethylamine; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; water; isopropyl alcohol; 3: Suzuki coupling;
DOI:10.1016/j.bmc.2011.04.008