(Z)-methyl 2-[cyano(2,4,4-trimethylpentan-2-ylimino)methyl]benzoate

Base Information

• Chemical Name: (Z)-methyl 2-[cyano(2,4,4-trimethylpentan-2-ylimino)methyl]benzoate
• CAS No.: 1615677-42-3
• Molecular Formula: C₁₈H₂₄N₂O₂
• Molecular Weight: 300.401
• Mol file: 1615677-42-3.mol

Synonyms:(Z)-methyl 2-[cyano(2,4,4-trimethylpentan-2-ylimino)methyl]benzoate

Chemical Property of (Z)-methyl 2-[cyano(2,4,4-trimethylpentan-2-ylimino)methyl]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (Z)-methyl 2-[cyano(2,4,4-trimethylpentan-2-ylimino)methyl]benzoate

There total 3 articles about (Z)-methyl 2-[cyano(2,4,4-trimethylpentan-2-ylimino)methyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N-[3-cyano-3-methoxy-1(3H)-isobenzofuranylidene]-2,4,4-trimethyl-2-pentanamine (1449007-80-0) → (Z)-methyl 2-[cyano(2,4,4-trimethylpentan-2-ylimino)methyl]benzoate (1615677-42-3)

Guidance literature:

With diisobutylaluminium hydride; In hexane; at 0 - 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1021/om500408h

Reference yield: 47.0%

methyl cyanoformate (17640-15-2) + 1,1,3,3-tetramethylbutane isonitrile (14542-93-9) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → N-[3-cyano-3-methoxy-1(3H)-isobenzofuranylidene]-2,4,4-trimethyl-2-pentanamine (1449007-80-0) + (Z)-methyl 2-[cyano(2,4,4-trimethylpentan-2-ylimino)methyl]benzoate (1615677-42-3)

Guidance literature:

With potassium fluoride; [Pd(PhCN)₂(dppf)](BF₄)₂; 18-crown-6 ether; In tetrahydrofuran; at 50 ℃; for 18h; Schlenk technique; Inert atmosphere;

DOI:10.1021/om500408h

Reference yield:

1,1,3,3-tetramethylbutane isonitrile (14542-93-9) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → (Z)-methyl 2-[cyano(2,4,4-trimethylpentan-2-ylimino)methyl]benzoate (1615677-42-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium fluoride; 18-crown-6 ether; [Pd(PhCN)₂(dppf)](BF₄)₂ / tetrahydrofuran / 18 h / 50 °C / Schlenk technique; Inert atmosphere

2: diisobutylaluminium hydride / hexane / 0 - 20 °C / Inert atmosphere; Schlenk technique

With potassium fluoride; [Pd(PhCN)₂(dppf)](BF₄)₂; 18-crown-6 ether; diisobutylaluminium hydride; In tetrahydrofuran; hexane;

DOI:10.1021/om500408h

upstream raw materials:

1,1,3,3-tetramethylbutane isonitrile

2-(trimethylsilyl)phenyl trifluoromethanesulfonate

methyl cyanoformate

N-[3-cyano-3-methoxy-1(3H)-isobenzofuranylidene]-2,4,4-trimethyl-2-pentanamine