N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-leucinamide hydrochloride

Base Information

Chemical Name:N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-leucinamide hydrochloride
CAS No.:1269408-20-9
Molecular Formula:C₁₇H₂₃N₅O₃*ClH
Molecular Weight:381.862
Hs Code.:

N<sub>1</sub>-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-leucinamide hydrochloride

Synonyms:N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-leucinamide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-leucinamide hydrochloride

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Technology Process of N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-leucinamide hydrochloride

There total 4 articles about N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-leucinamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1269406-78-1
N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-L-leucinamide

: 1269408-20-9
N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-leucinamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 - 50 ℃; for 20h;

Reference yield:

: 17417-09-3
2-fluoro-5-nitrobenzonitrile

: 1269408-20-9
N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-leucinamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 1 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: triethylamine; HATU / dichloromethane / 2 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 20 h / 20 - 50 °C

With hydrogenchloride; potassium carbonate; triethylamine; HATU; In 1,4-dioxane; dichloromethane; acetonitrile;

Reference yield:

: 1269406-69-0
1,1-dimethylethyl [(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]carbamate

: 1269408-20-9
N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-leucinamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2: triethylamine; HATU / dichloromethane / 2 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 20 h / 20 - 50 °C

With hydrogenchloride; triethylamine; HATU; In 1,4-dioxane; dichloromethane;