2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl 1-(1-(2-chloro-6-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate

Base Information

Chemical Name:2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl 1-(1-(2-chloro-6-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate
CAS No.:1565835-91-7
Molecular Formula:C₄₁H₄₁ClFN₅O₂
Molecular Weight:690.26
Hs Code.:

Synonyms:2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl 1-(1-(2-chloro-6-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate

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Chemical Property of 2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl 1-(1-(2-chloro-6-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate

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Technology Process of 2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl 1-(1-(2-chloro-6-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate

There total 12 articles about 2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl 1-(1-(2-chloro-6-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1440753-69-4
2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethanol

: 1565835-89-3
1-(1-(2-chloro-6-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylic acid

: 1565835-91-7
2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl 1-(1-(2-chloro-6-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate

Guidance literature:: With di-tert-butyl azodicarboxylate; In tetrahydrofuran; at 20 - 100 ℃; for 0.5h;
DOI:10.1021/jm500632s

Reference yield: 56.0%

: 1565835-91-7
2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl 1-(1-(2-chloro-6-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate

Guidance literature:: With di-tert-butyl-diazodicarboxylate; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 16h;

Reference yield:

: 4857-06-1
2-chloro-1H-benzoimidazole

: 1565835-91-7
2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl 1-(1-(2-chloro-6-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; 1-methyl-pyrrolidin-2-one / 90 °C

2: caesium carbonate / acetonitrile / 20 °C

3: hydrogenchloride / 1,4-dioxane; water / 48 h / 20 °C

4: di-tert-butyl azodicarboxylate / tetrahydrofuran / 0.5 h / 20 - 100 °C

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; di-tert-butyl azodicarboxylate; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile; 4: |Mitsunobu Displacement;
DOI:10.1021/jm500632s