7-bromo-1-tert-butyloxycarbonylmethyl-3-hydroxy-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one

Base Information

• Chemical Name: 7-bromo-1-tert-butyloxycarbonylmethyl-3-hydroxy-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one
• CAS No.: 130788-50-0
• Molecular Formula: C₂₁H₂₀BrClN₂O₄
• Molecular Weight: 479.758

Synonyms:7-bromo-1-tert-butyloxycarbonylmethyl-3-hydroxy-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one

Chemical Property of 7-bromo-1-tert-butyloxycarbonylmethyl-3-hydroxy-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one

Chemical Property:

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Technology Process of 7-bromo-1-tert-butyloxycarbonylmethyl-3-hydroxy-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one

There total 5 articles about 7-bromo-1-tert-butyloxycarbonylmethyl-3-hydroxy-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-acetoxy-7-bromo-1-tert-butyloxycarbonylmethyl-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one (130788-51-1) → 7-bromo-1-tert-butyloxycarbonylmethyl-3-hydroxy-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one (130788-50-0)

Guidance literature:

With sodium hydroxide; In methanol; water; for 0.0833333h;

DOI:10.1007/BF00487438

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → 7-bromo-1-tert-butyloxycarbonylmethyl-3-hydroxy-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one (130788-50-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 30 min, 2.) 3 h

2: 92 percent / NaOH / methanol; H₂O / 0.08 h

With sodium hydroxide; sodium hydride; In methanol; water;

DOI:10.1007/BF00487438

Reference yield:

7-bromo-1-tert-butyloxycarbonylmethyl-5-(2-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepin-2-one (126494-59-5) → 7-bromo-1-tert-butyloxycarbonylmethyl-3-hydroxy-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one (130788-50-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaI / 1.) AcOH, 60 deg, 15 min, 2.) 60 deg C, 1 h

2: 92 percent / NaOH / methanol; H₂O / 0.08 h

With sodium hydroxide; sodium iodide; In methanol; water;

DOI:10.1007/BF00487438

upstream raw materials:

3-acetoxy-7-bromo-1-tert-butyloxycarbonylmethyl-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one

bromoacetic acid tert-butyl ester

7-bromo-1-tert-butyloxycarbonylmethyl-5-(2-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepin-2-one

3-acetoxy-7-bromo-5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Downstream raw materials:

7-bromo-3-hydroxy-1-carboxymethyl-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one

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