1-[8-allyloxy-1-allyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl]-2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-propan-1-one

Base Information

Chemical Name:1-[8-allyloxy-1-allyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl]-2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-propan-1-one
CAS No.:866110-87-4
Molecular Formula:C₄₄H₇₂N₂O₉Si₂
Molecular Weight:829.235
Hs Code.:

1-[8-allyloxy-1-allyloxymethyl-3-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-3,4-dihydro-1<i>H</i>-isoquinolin-2-yl]-2-amino-3-[5-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-propan-1-one

Synonyms:1-[8-allyloxy-1-allyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl]-2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-propan-1-one

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Chemical Property of 1-[8-allyloxy-1-allyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl]-2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-propan-1-one

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Technology Process of 1-[8-allyloxy-1-allyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl]-2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-propan-1-one

There total 7 articles about 1-[8-allyloxy-1-allyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl]-2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 866110-76-1
C₅₉H₈₂N₂O₁₁Si₂

: 866110-87-4
1-[8-allyloxy-1-allyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl]-2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-propan-1-one

Guidance literature:: With piperidine; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1021/ja0535918

Reference yield:

: (S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-2-((R)-1,2-diphenyl-ethyl)-1-hydroxymethyl-5,7-dimethoxy-6-methyl-1,2,3,4-tetrahydro-isoquinolin-8-ol

: 866110-87-4
1-[8-allyloxy-1-allyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl]-2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-propan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 69 percent / H₂ / Pd/C / ethanol / 3 h / 20 °C / 760 Torr

2.1: KHMDS / tetrahydrofuran; toluene / 0.75 h / -50 °C

2.2: tetrahydrofuran; toluene / 12 h / 20 °C

3.1: 42 mg / 2,6-lutidine; TMS-OTf / CH₂Cl₂ / 2 h / 20 °C

4.1: 123 mg / 2,6-lutidine / CH₂Cl₂ / 12 h / 20 °C

5.1: 86 mg / piperidine / CH₂Cl₂ / 6 h / 20 °C

With piperidine; 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate; hydrogen; potassium hexamethylsilazane; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1021/ja0535918

Reference yield:

: 866110-67-0
(1R,3S)-8-Allyloxy-1-allyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-1,2,3,4-tetrahydro-isoquinoline

: 866110-87-4
1-[8-allyloxy-1-allyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl]-2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 123 mg / 2,6-lutidine / CH₂Cl₂ / 12 h / 20 °C

2: 86 mg / piperidine / CH₂Cl₂ / 6 h / 20 °C

With piperidine; 2,6-dimethylpyridine; In dichloromethane;
DOI:10.1021/ja0535918