4,7-dihydro-4-oxo-2-[(triphenylmethyl)amino]-3H-pyrrolo[2,3-d]pyrimidine-5-carboxaldehyde

Base Information

• Chemical Name: 4,7-dihydro-4-oxo-2-[(triphenylmethyl)amino]-3H-pyrrolo[2,3-d]pyrimidine-5-carboxaldehyde
• CAS No.: 1019853-65-6
• Molecular Formula: C₂₆H₂₀N₄O₂
• Molecular Weight: 420.47
• Mol file: 1019853-65-6.mol

Synonyms:4,7-dihydro-4-oxo-2-[(triphenylmethyl)amino]-3H-pyrrolo[2,3-d]pyrimidine-5-carboxaldehyde

Chemical Property of 4,7-dihydro-4-oxo-2-[(triphenylmethyl)amino]-3H-pyrrolo[2,3-d]pyrimidine-5-carboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4,7-dihydro-4-oxo-2-[(triphenylmethyl)amino]-3H-pyrrolo[2,3-d]pyrimidine-5-carboxaldehyde

There total 1 articles about 4,7-dihydro-4-oxo-2-[(triphenylmethyl)amino]-3H-pyrrolo[2,3-d]pyrimidine-5-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4,7-dihydro-4-oxo-2-[(triphenylmethyl)amino]-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (1019853-64-5) → 4,7-dihydro-4-oxo-2-[(triphenylmethyl)amino]-3H-pyrrolo[2,3-d]pyrimidine-5-carboxaldehyde (1019853-65-6)

Guidance literature:

4,7-dihydro-4-oxo-2-[(triphenylmethyl)amino]-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile; With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; In toluene; Reflux;

With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; for 3h; Inert atmosphere;

With water; In dichloromethane; ethyl acetate; toluene; for 2h;

Reference yield: 100.0%

4,7-dihydro-4-oxo-2-[(triphenylmethyl)amino]-3H-pyrrolo[2,3-d]pyrimidine-5-carboxaldehyde (1019853-65-6) + Triphenylmethylamin (5824-40-8) → C45H35N5O (1310057-20-5)

Guidance literature:

With sodium sulfate; In tetrahydrofuran; for 6h; Reflux;

DOI:10.1093/nar/gkq1188

Reference yield: 99.0%

4,7-dihydro-4-oxo-2-[(triphenylmethyl)amino]-3H-pyrrolo[2,3-d]pyrimidine-5-carboxaldehyde (1019853-65-6) → 5-(hydroxymethyl)-2-(tritylamino)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

Guidance literature:

With sodium tetrahydroborate; In methanol; for 3h; Cooling with ice;

DOI:10.1002/jhet.4220

upstream raw materials:

4,7-dihydro-4-oxo-2-[(triphenylmethyl)amino]-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Downstream raw materials:

C₃₃H₂₅F₂N₅O

C₃₃H₂₆FN₅O

7-formyl-7-deazaguanine

C₃₄H₃₁N₅O₃