N-im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine

Base Information

• Chemical Name: N-im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine
• CAS No.: 106162-46-3
• Molecular Formula: C₄₂H₆₃N₇O₈S
• Molecular Weight: 826.07

Synonyms:N-im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine

Chemical Property of N-im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine

There total 6 articles about N-im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(2S,4S,5S)-5-Amino-4-hydroxy-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide; hydrochloride + Boc-His(Tos)-OH (35899-43-5) → N-im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine (106162-46-3)

Guidance literature:

With diethylphosphoryl cyanide; triethylamine; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00386a016

Reference yield:

2-(Aminomethyl)pyridine (3731-51-9) → N-im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine (106162-46-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 88 percent / 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / Ambient temperature

2: 100 percent / trifluoroacetic acid / CH₂Cl₂ / Ambient temperature

3: 100 percent / triethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂ / Ambient temperature

4: gas HCl / diethyl ether / 0.33 h / Ambient temperature

5: 65 percent / triethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂ / Ambient temperature

With hydrogenchloride; diethylphosphoryl cyanide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In diethyl ether; dichloromethane;

DOI:10.1021/jm00386a016

Reference yield:

N-(tert-butyloxycarbonyl)-L-isoleucine (13139-16-7) → N-im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine (106162-46-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 88 percent / 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / Ambient temperature

2: 100 percent / trifluoroacetic acid / CH₂Cl₂ / Ambient temperature

3: 100 percent / triethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂ / Ambient temperature

4: gas HCl / diethyl ether / 0.33 h / Ambient temperature

5: 65 percent / triethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂ / Ambient temperature

With hydrogenchloride; diethylphosphoryl cyanide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In diethyl ether; dichloromethane;

DOI:10.1021/jm00386a016

upstream raw materials:

(2S,4S,5S)-5-Amino-4-hydroxy-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide; hydrochloride

Boc-His(Tos)-OH

2-(Aminomethyl)pyridine

N-(tert-butyloxycarbonyl)-L-isoleucine

Downstream raw materials:

(2S,4S,5S)-5-{(S)-2-Amino-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionylamino}-4-hydroxy-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

(phenylacetyl)-L-histidyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-L-isoleucyl-2-pyridylmethylamine

(2S,4S,5S)-4-Hydroxy-5-[(S)-3-(1H-imidazol-4-yl)-2-(2-phenoxy-acetylamino)-propionylamino]-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

(phenylacetyl)-N^im-tosyl-L-histidyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-L-isoleucyl-2-pyridylmethylamine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 106162-46-3 N-im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send