Technology Process of (3S,4S)-3-Benzyloxy-4-methyl-1-nitro-hexan-2-ol
There total 6 articles about (3S,4S)-3-Benzyloxy-4-methyl-1-nitro-hexan-2-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: oxalyl chloride; dimethyl sulfoxide; triethylamine / CH2Cl2 / 5 h / -70 - -60 °C
2: triethylamine / 16 h / 20 °C
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
2: Henry reaction;
DOI:10.1002/anie.200462497
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium aluminum hydride / diethyl ether / 3 h / 20 °C
2: oxalyl chloride; dimethyl sulfoxide; triethylamine / CH2Cl2 / 5 h / -70 - -60 °C
3: triethylamine / 16 h / 20 °C
With
lithium aluminium tetrahydride; oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
diethyl ether; dichloromethane;
3: Henry reaction;
DOI:10.1002/anie.200462497
- Guidance literature:
-
Multi-step reaction with 6 steps
1: NaNO2; H2SO4 / H2O / 24 h / 0 °C
2: p-toluenesulfonic acid monohydrate / methanol / 24 h / 45 °C
3: NaH / tetrahydrofuran; dimethylformamide / 0 - 20 °C
4: lithium aluminum hydride / diethyl ether / 3 h / 20 °C
5: oxalyl chloride; dimethyl sulfoxide; triethylamine / CH2Cl2 / 5 h / -70 - -60 °C
6: triethylamine / 16 h / 20 °C
With
lithium aluminium tetrahydride; oxalyl dichloride; sulfuric acid; sodium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; sodium nitrite;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
3: Williamson reaction / 6: Henry reaction;
DOI:10.1002/anie.200462497
