diethyl 4-(3',4'-dichlorophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate

Base Information

• Chemical Name: diethyl 4-(3',4'-dichlorophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate
• CAS No.: 4408-97-3
• Molecular Formula: C₁₉H₁₉Cl₂NO₄
• Molecular Weight: 396.27
• Mol file: 4408-97-3.mol

Synonyms:diethyl 4-(3',4'-dichlorophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate

Chemical Property of diethyl 4-(3',4'-dichlorophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 4-(3',4'-dichlorophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate

There total 5 articles about diethyl 4-(3',4'-dichlorophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

diethyl-4-(3,4-dichlorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate → diethyl 4-(3',4'-dichlorophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate (4408-97-3)

Guidance literature:

With hydrogenchloride; sodium chlorite; In ethanol; water; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2010.05.091

Reference yield:

ethyl acetoacetate (141-97-9) + 3,4-dichlorobenzaldehyde (6287-38-3) → diethyl 4-(3',4'-dichlorophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate (4408-97-3)

Guidance literature:

With 10% Pd on charcoal; K-10 montmorillonite; ammonium acetate; In methanol; at 130 ℃; for 2h; Microwave irradiation;

DOI:10.1055/s-0028-1083177

Reference yield:

ethyl acetoacetate (141-97-9) → diethyl 4-(3',4'-dichlorophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate (4408-97-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NH₄OAc / H₂O / 1 h / Heating

2: KMnO₄; aq. AcOH / 3 h / Heating

With potassium permanganate; ammonium acetate; acetic acid; In water;

DOI:10.1055/s-2005-870022

upstream raw materials:

ethyl acetoacetate

3,4-dichlorobenzaldehyde