2-(5-cyano-2-(2-methoxy-4-morpholinophenylamino)pyridin-4-ylamino)-N-methylbenzamide trifluoroacetate

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Chemical Name:2-(5-cyano-2-(2-methoxy-4-morpholinophenylamino)pyridin-4-ylamino)-N-methylbenzamide trifluoroacetate
CAS No.:1061355-73-4
Molecular Formula:C₂HF₃O₂*C₂₅H₂₆N₆O₃
Molecular Weight:572.544
Hs Code.:

Synonyms:2-(5-cyano-2-(2-methoxy-4-morpholinophenylamino)pyridin-4-ylamino)-N-methylbenzamide trifluoroacetate

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Chemical Property of 2-(5-cyano-2-(2-methoxy-4-morpholinophenylamino)pyridin-4-ylamino)-N-methylbenzamide trifluoroacetate

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Technology Process of 2-(5-cyano-2-(2-methoxy-4-morpholinophenylamino)pyridin-4-ylamino)-N-methylbenzamide trifluoroacetate

There total 3 articles about 2-(5-cyano-2-(2-methoxy-4-morpholinophenylamino)pyridin-4-ylamino)-N-methylbenzamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 209960-91-8
2-methoxy-4-morpholinoaniline

: 1061358-90-4
2-(2-bromo-5-cyanopyridin-4-ylamino)-N-methylbenzamide

: 1061355-73-4
2-(5-cyano-2-(2-methoxy-4-morpholinophenylamino)pyridin-4-ylamino)-N-methylbenzamide trifluoroacetate

Guidance literature:: With 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichlorobenzene, 1,2-; at 90 ℃; for 16h;

Reference yield:

: 6950-88-5
4-(3-methoxy-4-nitro-phenyl)morpholine

: 1061355-73-4
2-(5-cyano-2-(2-methoxy-4-morpholinophenylamino)pyridin-4-ylamino)-N-methylbenzamide trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 18 h

2: 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / dichlorobenzene, 1,2- / 16 h / 90 °C

With hydrogen; 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In methanol; dichlorobenzene, 1,2-; 2: Buchwald-Hartwig amination;

Reference yield:

: 448-19-1
4-fluoro-2-methoxy-1-nitrobenzene

: 1061355-73-4
2-(5-cyano-2-(2-methoxy-4-morpholinophenylamino)pyridin-4-ylamino)-N-methylbenzamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 18 h

3: 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / dichlorobenzene, 1,2- / 16 h / 90 °C

With hydrogen; potassium carbonate; 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In methanol; dichlorobenzene, 1,2-; N,N-dimethyl-formamide; 3: Buchwald-Hartwig amination;