Technology Process of 3-ethoxy-6,7-dihydro-8-phenyl-9-(4-hydroxyphenyl)-5H-benzocycloheptene
There total 9 articles about 3-ethoxy-6,7-dihydro-8-phenyl-9-(4-hydroxyphenyl)-5H-benzocycloheptene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-ethoxy-6,7-dihydro-8-phenyl-9-(4-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)phenyl)-5H-benzocycloheptene;
With
sodium methylate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 4h;
Inert atmosphere;
With
sodium hydrogencarbonate;
In
N,N-dimethyl-formamide;
Inert atmosphere;
DOI:10.1021/jm500569h
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetone / 20 °C / Inert atmosphere
2.1: ethylene dibromide; magnesium / diethyl ether / 1.5 h / Inert atmosphere; Heating
2.2: 10 h / 20 °C / Inert atmosphere
3.1: hydrogenchloride / ethanol / 2 h / Inert atmosphere; Reflux
4.1: pyridinium hydrobromide perbromide / dichloromethane / 4 h / 20 °C / Inert atmosphere
5.1: zinc(II) chloride / tetrahydrofuran; dibutyl ether / 0.25 h / 20 °C / Inert atmosphere
5.2: 3 h / Inert atmosphere; Reflux
6.1: sodium methylate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere
6.2: Inert atmosphere
With
hydrogenchloride; sodium methylate; potassium carbonate; magnesium; pyridinium hydrobromide perbromide; ethylene dibromide; zinc(II) chloride;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; dibutyl ether; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm500569h
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: aluminum (III) chloride / toluene / Reflux
2.1: potassium carbonate / acetone / 20 °C / Inert atmosphere
3.1: ethylene dibromide; magnesium / diethyl ether / 1.5 h / Inert atmosphere; Heating
3.2: 10 h / 20 °C / Inert atmosphere
4.1: hydrogenchloride / ethanol / 2 h / Inert atmosphere; Reflux
5.1: pyridinium hydrobromide perbromide / dichloromethane / 4 h / 20 °C / Inert atmosphere
6.1: zinc(II) chloride / tetrahydrofuran; dibutyl ether / 0.25 h / 20 °C / Inert atmosphere
6.2: 3 h / Inert atmosphere; Reflux
7.1: sodium methylate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere
7.2: Inert atmosphere
With
hydrogenchloride; aluminum (III) chloride; sodium methylate; potassium carbonate; magnesium; pyridinium hydrobromide perbromide; ethylene dibromide; zinc(II) chloride;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; dibutyl ether; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/jm500569h
