(2R,5R)-5-but-3-enyl-2-ethynylpyrrolidine-1-carboxylic acid 1-benzyl ester

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Chemical Name:(2R,5R)-5-but-3-enyl-2-ethynylpyrrolidine-1-carboxylic acid 1-benzyl ester
CAS No.:690211-37-1
Molecular Formula:C₁₈H₂₁NO₂
Molecular Weight:283.37
Hs Code.:

Synonyms:(2R,5R)-5-but-3-enyl-2-ethynylpyrrolidine-1-carboxylic acid 1-benzyl ester

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Chemical Property of (2R,5R)-5-but-3-enyl-2-ethynylpyrrolidine-1-carboxylic acid 1-benzyl ester

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Technology Process of (2R,5R)-5-but-3-enyl-2-ethynylpyrrolidine-1-carboxylic acid 1-benzyl ester

There total 5 articles about (2R,5R)-5-but-3-enyl-2-ethynylpyrrolidine-1-carboxylic acid 1-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 760968-59-0
(2R)-but-3-enyl-(5R)-2-(1-methylsiletan-1-ylethynyl)pyrrolidine-1-carboxylic acid benzyl ester

: (1R,6R)-2-Vinyl-9-aza-bicyclo[4.2.1]non-2-ene-9-carboxylic acid benzyl ester

: 690211-37-1
(2R,5R)-5-but-3-enyl-2-ethynylpyrrolidine-1-carboxylic acid 1-benzyl ester

Guidance literature:: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 80 ℃;
DOI:10.1016/j.tet.2004.06.021

Reference yield:

: 90965-06-3
dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

: (2R,5R)-2-But-3-enyl-5-formyl-pyrrolidine-1-carboxylic acid benzyl ester

: 690211-37-1
(2R,5R)-5-but-3-enyl-2-ethynylpyrrolidine-1-carboxylic acid 1-benzyl ester

Guidance literature:: With caesium carbonate; In tert-butyl alcohol;
DOI:10.1021/ol049631e

Reference yield:

: 90965-06-3
dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

: 690211-35-9
(2R)-benzyloxycarbonylamino-5-oxonon-8-enoic acid methyl ester

: 690211-37-1
(2R,5R)-5-but-3-enyl-2-ethynylpyrrolidine-1-carboxylic acid 1-benzyl ester

: (2S,5R)-2-But-3-enyl-5-ethynyl-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: (2R)-benzyloxycarbonylamino-5-oxonon-8-enoic acid methyl ester; With boron trifluoride diethyl etherate; HSiPh₃; In dichloromethane; at -78 - 20 ℃; for 2.5h;

With diisobutylaluminium hydride; In toluene; at -78 ℃; for 3h;

dimethyl 1-(1-diazo-2-oxopropyl)phosphonate; With caesium carbonate; In isopropyl alcohol; toluene; at 20 ℃; for 17h; Further stages.;
DOI:10.1016/j.tet.2004.06.021