Technology Process of (3R,4S,5R)-methyl 3,4-dibenzyloxy-5-hydroxycyclohex-1-ene-1-carboxylate
There total 9 articles about (3R,4S,5R)-methyl 3,4-dibenzyloxy-5-hydroxycyclohex-1-ene-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: diethylaluminium chloride / CH2Cl2 / 120 h / -20 °C
2: 84 percent / PBr3 / dimethylformamide / 0 °C
3: 95 percent / lithium aluminium hydride / diethyl ether / Ambient temperature
4: 45 percent / Raney Ni (W-2) / ethanol / Ambient temperature
5: Jones reagent / acetone / Ambient temperature
6: diethyl ether; methanol
7: 56 percent / lithium hexamethyldisilazide / tetrahydrofuran / -78 °C
With
lithium aluminium tetrahydride; jones reagent; diethylaluminium chloride; phosphorus tribromide; lithium hexamethyldisilazane;
Raney Ni (W-2);
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 45 percent / Raney Ni (W-2) / ethanol / Ambient temperature
2: Jones reagent / acetone / Ambient temperature
3: diethyl ether; methanol
4: 56 percent / lithium hexamethyldisilazide / tetrahydrofuran / -78 °C
With
jones reagent; lithium hexamethyldisilazane;
Raney Ni (W-2);
In
tetrahydrofuran; methanol; diethyl ether; ethanol; acetone;