7(S)-7-deoxy-7-(5-(4-(difluoromethylthio)phenylamino)-1,3,4-thiadiazol-2-ylthio)lincomycin

Base Information

Chemical Name:7(S)-7-deoxy-7-(5-(4-(difluoromethylthio)phenylamino)-1,3,4-thiadiazol-2-ylthio)lincomycin
CAS No.:941586-41-0
Molecular Formula:C₂₇H₃₉F₂N₅O₅S₄
Molecular Weight:679.898
Hs Code.:

Synonyms:7(S)-7-deoxy-7-(5-(4-(difluoromethylthio)phenylamino)-1,3,4-thiadiazol-2-ylthio)lincomycin

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Chemical Property of 7(S)-7-deoxy-7-(5-(4-(difluoromethylthio)phenylamino)-1,3,4-thiadiazol-2-ylthio)lincomycin

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Technology Process of 7(S)-7-deoxy-7-(5-(4-(difluoromethylthio)phenylamino)-1,3,4-thiadiazol-2-ylthio)lincomycin

There total 2 articles about 7(S)-7-deoxy-7-(5-(4-(difluoromethylthio)phenylamino)-1,3,4-thiadiazol-2-ylthio)lincomycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 25420-97-7
2,3,4-tris-O-(trimethylsilyl)lincomycin

: 571149-73-0
5-(4-(difluoromethylthio)phenylamino)-1,3,4-thiadiazole-2-thiol

: 941586-41-0
7(S)-7-deoxy-7-(5-(4-(difluoromethylthio)phenylamino)-1,3,4-thiadiazol-2-ylthio)lincomycin

Guidance literature:: 2,3,4-tris-O-(trimethylsilyl)lincomycin; 5-(4-(difluoromethylthio)phenylamino)-1,3,4-thiadiazole-2-thiol; With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 20 ℃; for 0.5h;
DOI:10.1038/ja.2015.119

Reference yield:

: 154-21-2
lincomycin

: 941586-41-0
7(S)-7-deoxy-7-(5-(4-(difluoromethylthio)phenylamino)-1,3,4-thiadiazol-2-ylthio)lincomycin

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; 1,1,1,3,3,3-hexamethyl-disilazane / 2 h / 20 °C

1.2: 16 h / 20 °C

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran

2.2: 0.5 h / 20 °C

With pyridine; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; diethylazodicarboxylate; In tetrahydrofuran; 2.1: |Mitsunobu Displacement;
DOI:10.1038/ja.2015.119