4-Methyl-N-(2-methylsulfanyl-4-phenyl-imidazol-1-yl)-benzimidoyl chloride

Base Information

• Chemical Name: 4-Methyl-N-(2-methylsulfanyl-4-phenyl-imidazol-1-yl)-benzimidoyl chloride
• CAS No.: 120492-33-3
• Molecular Formula: C₁₈H₁₆ClN₃S
• Molecular Weight: 341.864

Synonyms:4-Methyl-N-(2-methylsulfanyl-4-phenyl-imidazol-1-yl)-benzimidoyl chloride

Chemical Property of 4-Methyl-N-(2-methylsulfanyl-4-phenyl-imidazol-1-yl)-benzimidoyl chloride

Chemical Property:

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Technology Process of 4-Methyl-N-(2-methylsulfanyl-4-phenyl-imidazol-1-yl)-benzimidoyl chloride

There total 2 articles about 4-Methyl-N-(2-methylsulfanyl-4-phenyl-imidazol-1-yl)-benzimidoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-methyl-benzoyl chloride (874-60-2) + 2-methylthio-4-phenyl-1-triphenylphosphoranylideneaminoimidazole (120492-31-1) → 4-Methyl-N-(2-methylsulfanyl-4-phenyl-imidazol-1-yl)-benzimidoyl chloride (120492-33-3)

Guidance literature:

In toluene; for 15h; Heating;

DOI:10.3987/COM-88-4602

Reference yield:

1-amino-2-methylthio-4-phenyl-1H-imidazole (38036-89-4) → 4-Methyl-N-(2-methylsulfanyl-4-phenyl-imidazol-1-yl)-benzimidoyl chloride (120492-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) bromine; 2.) triethylamine / 1.) benzene, 1 h, 0-5 degC; 2.) reflux, 12 h

2: 60 percent / toluene / 15 h / Heating

With bromine; triethylamine; In toluene;

DOI:10.3987/COM-88-4602

Reference yield: 79.0%

4-Methyl-N-(2-methylsulfanyl-4-phenyl-imidazol-1-yl)-benzimidoyl chloride (120492-33-3) → 4-Methyl-N-(2-methylsulfanyl-4-phenyl-imidazol-1-yl)-benzimidoyl azide

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; for 5h; Ambient temperature;

DOI:10.1055/s-1989-27406

upstream raw materials:

4-methyl-benzoyl chloride

2-methylthio-4-phenyl-1-triphenylphosphoranylideneaminoimidazole

1-amino-2-methylthio-4-phenyl-1H-imidazole

Downstream raw materials:

Methyl-(7-methylsulfanyl-5-phenyl-2-p-tolyl-imidazo[5,1-f][1,2,4]triazin-4-yl)-amine

(7-Methylsulfanyl-5-phenyl-2-p-tolyl-imidazo[5,1-f][1,2,4]triazin-4-yl)-m-tolyl-amine

(4-Chloro-phenyl)-(7-methylsulfanyl-5-phenyl-2-p-tolyl-imidazo[5,1-f][1,2,4]triazin-4-yl)-amine

(7-Methylsulfanyl-5-phenyl-2-p-tolyl-imidazo[5,1-f][1,2,4]triazin-4-yl)-naphthalen-1-yl-amine

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