5-bromo-3-n-butyl-4-methyl-2-p-toluenesulfonylpyrrole

Base Information

• Chemical Name: 5-bromo-3-n-butyl-4-methyl-2-p-toluenesulfonylpyrrole
• CAS No.: 311767-36-9
• Molecular Formula: C₁₆H₂₀BrNO₂S
• Molecular Weight: 370.31
• Mol file: 311767-36-9.mol

Synonyms:5-bromo-3-n-butyl-4-methyl-2-p-toluenesulfonylpyrrole

Chemical Property of 5-bromo-3-n-butyl-4-methyl-2-p-toluenesulfonylpyrrole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-bromo-3-n-butyl-4-methyl-2-p-toluenesulfonylpyrrole

There total 4 articles about 5-bromo-3-n-butyl-4-methyl-2-p-toluenesulfonylpyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-n-butyl-4-methyl-2-p-toluenesulfonyl-1H-pyrrole (311767-38-1) → 5-bromo-3-n-butyl-4-methyl-2-p-toluenesulfonylpyrrole (311767-36-9)

Guidance literature:

With phenyltrimethylammonium tribromide; In dichloromethane; at 0 ℃; for 0.333333h;

DOI:10.1016/S0040-4020(00)00710-9

Reference yield: 28.0%

3-n-butyl-4-methyl-2-p-toluenesulfonyl-1H-pyrrole (311767-38-1) → 5-bromo-4-n-butyl-3-methyl-2-p-toluenesulfonyl-1H-pyrrole (311767-35-8) + 5-bromo-3-n-butyl-4-methyl-2-p-toluenesulfonylpyrrole (311767-36-9)

Guidance literature:

3-n-butyl-4-methyl-2-p-toluenesulfonyl-1H-pyrrole; With trifluoroacetic acid; In dichloromethane; for 24h;

With phenyl-N,N,N-trimethylammonium tribromide; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/jo0511041

Reference yield:

2-nitro-3-heptyl acetate (90950-91-7) → 5-bromo-3-n-butyl-4-methyl-2-p-toluenesulfonylpyrrole (311767-36-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / 1,1,3,3-tetramethylguanidine / propan-2-ol; tetrahydrofuran / 72 h / 20 °C

2: 100 percent / phenyltrimethylammonium tribromide / CH₂Cl₂ / 0.33 h / 0 °C

With phenyltrimethylammonium tribromide; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; dichloromethane; isopropyl alcohol; 1: Condensation / 2: Bromination;

DOI:10.1016/S0040-4020(00)00710-9

upstream raw materials:

3-n-butyl-4-methyl-2-p-toluenesulfonyl-1H-pyrrole

2-nitro-3-heptyl acetate

[(p-methylphenyl)sulfonylmethyl]isonitrile

Downstream raw materials:

3-methyl-4-n-butyl-5-(p-tosyl)-3-pyrrolin-2-one