(2R,3R,4R)-3-Benzyloxy-2-(2,2-diphenyl-ethyl)-4-(2-methoxy-phenoxy)-tetrahydro-pyran

Base Information

Chemical Name:(2R,3R,4R)-3-Benzyloxy-2-(2,2-diphenyl-ethyl)-4-(2-methoxy-phenoxy)-tetrahydro-pyran
CAS No.:291273-57-9
Molecular Formula:C₃₃H₃₄O₄
Molecular Weight:494.631
Hs Code.:

Synonyms:(2R,3R,4R)-3-Benzyloxy-2-(2,2-diphenyl-ethyl)-4-(2-methoxy-phenoxy)-tetrahydro-pyran

Suppliers and Price of (2R,3R,4R)-3-Benzyloxy-2-(2,2-diphenyl-ethyl)-4-(2-methoxy-phenoxy)-tetrahydro-pyran

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R,4R)-3-Benzyloxy-2-(2,2-diphenyl-ethyl)-4-(2-methoxy-phenoxy)-tetrahydro-pyran

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2R,3R,4R)-3-Benzyloxy-2-(2,2-diphenyl-ethyl)-4-(2-methoxy-phenoxy)-tetrahydro-pyran

There total 4 articles about (2R,3R,4R)-3-Benzyloxy-2-(2,2-diphenyl-ethyl)-4-(2-methoxy-phenoxy)-tetrahydro-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 101-81-5
Diphenylmethane

: 291273-54-6
Toluene-4-sulfonic acid (2R,3S,4R)-3-benzyloxy-4-(2-methoxy-phenoxy)-tetrahydro-pyran-2-ylmethyl ester

: 291273-57-9
(2R,3R,4R)-3-Benzyloxy-2-(2,2-diphenyl-ethyl)-4-(2-methoxy-phenoxy)-tetrahydro-pyran

Guidance literature:: Diphenylmethane; With n-butyllithium; In tetrahydrofuran; hexane; for 1.5h;

Toluene-4-sulfonic acid (2R,3S,4R)-3-benzyloxy-4-(2-methoxy-phenoxy)-tetrahydro-pyran-2-ylmethyl ester; In tetrahydrofuran; hexane; for 0.5h; Further stages.;
DOI:10.1021/ja001643h

Reference yield:

: 135214-83-4
1,5-Anhydro-2-deoxy-4,6-O-(phenylmethylene)-D-arabino-hexopyranoside

: 291273-57-9
(2R,3R,4R)-3-Benzyloxy-2-(2,2-diphenyl-ethyl)-4-(2-methoxy-phenoxy)-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran; various solvent(s) / 0.33 h / 20 °C

1.2: tetrahydrofuran; various solvent(s) / 3 h / 20 °C

1.3: 96 percent / I₂ / tetrahydrofuran; various solvent(s) / 0.5 h / 20 °C

2.1: 95 percent / DIBAL-H / CH₂Cl₂; toluene / 2 h / 20 °C

3.1: pyridine; DMAP / 10 h / 20 °C

4.1: BuLi / tetrahydrofuran; hexane / 1.5 h

4.2: 84 percent / tetrahydrofuran; hexane / 0.5 h

With pyridine; dmap; n-butyllithium; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1021/ja001643h

Reference yield:

: 291273-52-4
(2R,4aR,8R,8aS)-8-(2-Methoxy-phenoxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine

: 291273-57-9
(2R,3R,4R)-3-Benzyloxy-2-(2,2-diphenyl-ethyl)-4-(2-methoxy-phenoxy)-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / DIBAL-H / CH₂Cl₂; toluene / 2 h / 20 °C

2.1: pyridine; DMAP / 10 h / 20 °C

3.1: BuLi / tetrahydrofuran; hexane / 1.5 h

3.2: 84 percent / tetrahydrofuran; hexane / 0.5 h

With pyridine; dmap; n-butyllithium; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1021/ja001643h