(3R)-4-(1,1'-biphenyl-4-ylcarbonyl)-2-methylpiperazine hydrochloride

Base Information

• Chemical Name: (3R)-4-(1,1'-biphenyl-4-ylcarbonyl)-2-methylpiperazine hydrochloride
• CAS No.: 902766-08-9
• Molecular Formula: C₁₈H₂₀N₂O*ClH
• Molecular Weight: 316.831
• Mol file: 902766-08-9.mol

Synonyms:(3R)-4-(1,1'-biphenyl-4-ylcarbonyl)-2-methylpiperazine hydrochloride

Chemical Property of (3R)-4-(1,1'-biphenyl-4-ylcarbonyl)-2-methylpiperazine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (3R)-4-(1,1'-biphenyl-4-ylcarbonyl)-2-methylpiperazine hydrochloride

There total 1 articles about (3R)-4-(1,1'-biphenyl-4-ylcarbonyl)-2-methylpiperazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (3R)-4-(1,1'-biphenyl-4-ylcarbonyl)-3-methylpiperazine-1-carboxylate (902766-06-7) → (3R)-4-(1,1'-biphenyl-4-ylcarbonyl)-2-methylpiperazine hydrochloride (902766-08-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃;

Reference yield:

2,4-dichloro-6-ethyl-thieno-[2,3-d]-pyrimidine (87478-74-8) + (3R)-4-(1,1'-biphenyl-4-ylcarbonyl)-2-methylpiperazine hydrochloride (902766-08-9) → 4-[(3R)-4-(1,1'-biphenyl-4-ylcarbonyl)-3-methylpiperazin-1-yl]-2-chloro-6-ethylthieno[2,3-d]pyrimidine (902766-10-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

upstream raw materials:

tert-butyl (3R)-4-(1,1'-biphenyl-4-ylcarbonyl)-3-methylpiperazine-1-carboxylate

Downstream raw materials:

4-[(3R)-4-(1,1'-biphenyl-4-ylcarbonyl)-3-methylpiperazin-1-yl]-2-chloro-6-ethylthieno[2,3-d]pyrimidine