3,5-bis(4-carbamimidoylphenoxy)-N-(1-(2-hydroxyethyl)piperidin-4-yl)benzamide

Base Information

Chemical Name:3,5-bis(4-carbamimidoylphenoxy)-N-(1-(2-hydroxyethyl)piperidin-4-yl)benzamide
CAS No.:1256590-85-8
Molecular Formula:C₂₈H₃₂N₆O₄
Molecular Weight:516.6
Hs Code.:

Synonyms:3,5-bis(4-carbamimidoylphenoxy)-N-(1-(2-hydroxyethyl)piperidin-4-yl)benzamide

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Chemical Property of 3,5-bis(4-carbamimidoylphenoxy)-N-(1-(2-hydroxyethyl)piperidin-4-yl)benzamide

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Technology Process of 3,5-bis(4-carbamimidoylphenoxy)-N-(1-(2-hydroxyethyl)piperidin-4-yl)benzamide

There total 9 articles about 3,5-bis(4-carbamimidoylphenoxy)-N-(1-(2-hydroxyethyl)piperidin-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1611481-64-1
C₃₃H₄₀N₆O₅

: 1256590-85-8
3,5-bis(4-carbamimidoylphenoxy)-N-(1-(2-hydroxyethyl)piperidin-4-yl)benzamide

Guidance literature:: With hydrogenchloride; ethanol; at 5 - 10 ℃; for 2h;
DOI:10.1016/j.bmc.2014.04.013

Reference yield:

: 1256598-88-5
3,5-Bis-[4-(N-hydroxycarbamimidoyl)-phenoxy]-N-[1-(2-hydroxy-ethyl)-piperidin-4-yl]-benzamide

: 1256590-85-8
3,5-bis(4-carbamimidoylphenoxy)-N-(1-(2-hydroxyethyl)piperidin-4-yl)benzamide

Guidance literature:: With ammonium formate; acetic acid; palladium on activated charcoal; In methanol; at 60 ℃; for 5h; Inert atmosphere;

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 1256590-85-8
3,5-bis(4-carbamimidoylphenoxy)-N-(1-(2-hydroxyethyl)piperidin-4-yl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 80 °C

2.1: lithium hydroxide; water / tetrahydrofuran / 2 h

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 5 °C

3.2: 20 °C

4.1: hydroxylamine / ethanol; water / 6 h / 75 °C

5.1: acetic acid / 2 h / 20 °C

6.1: acetic acid; zinc / 20 °C

7.1: hydrogenchloride; ethanol / 2 h / 5 - 10 °C

With hydrogenchloride; ethanol; water; hydroxylamine; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; zinc; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.04.013