1-(4-bromo-phenyl)-2-(4-fluoro-phenyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline

Base Information

Chemical Name:1-(4-bromo-phenyl)-2-(4-fluoro-phenyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline
CAS No.:844431-64-7
Molecular Formula:C₂₂H₁₉BrFNO
Molecular Weight:412.301
Hs Code.:

Synonyms:1-(4-bromo-phenyl)-2-(4-fluoro-phenyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-bromo-phenyl)-2-(4-fluoro-phenyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline

Chemical Property:

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Technology Process of 1-(4-bromo-phenyl)-2-(4-fluoro-phenyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline

There total 4 articles about 1-(4-bromo-phenyl)-2-(4-fluoro-phenyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(4-bromo-phenyl)-2-(4-fluoro-phenyl)-6-methoxy-3,4-dihydro-isoquinolinium

: 844431-64-7
1-(4-bromo-phenyl)-2-(4-fluoro-phenyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃;
DOI:10.1021/jm040858p

Reference yield:

: 106-37-6
1.4-dibromobenzene

: 844431-64-7
1-(4-bromo-phenyl)-2-(4-fluoro-phenyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / hexane; tetrahydrofuran / -78 °C

1.2: tetrahydrofuran; hexane / -78 °C

2.1: NaBH₄ / methanol / 20 °C

With sodium tetrahydroborate; n-butyllithium; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/jm040858p

Reference yield:

: 22246-12-4
6-methoxy-1,2,3,4-tetrahydro-1-oxoisoquinoline

: 844431-64-7
1-(4-bromo-phenyl)-2-(4-fluoro-phenyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: K₂CO₃; CuI / dimethylformamide / 150 °C

2.1: n-BuLi / hexane; tetrahydrofuran / -78 °C

2.2: tetrahydrofuran; hexane / -78 °C

3.1: NaBH₄ / methanol / 20 °C

With sodium tetrahydroborate; copper(l) iodide; n-butyllithium; potassium carbonate; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm040858p