3(R)-[(2(S)-1-(tert-butoxycarbonyl)pyrrolidinylcarbonyl)amino]-2-oxo-1-(N-(N'-benzyloxycarbonylamino)ethyl)pyrrolidineacetamide

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Chemical Name:3(R)-[(2(S)-1-(tert-butoxycarbonyl)pyrrolidinylcarbonyl)amino]-2-oxo-1-(N-(N'-benzyloxycarbonylamino)ethyl)pyrrolidineacetamide
CAS No.:874163-19-6
Molecular Formula:C₂₆H₃₇N₅O₇
Molecular Weight:531.609
Hs Code.:

Synonyms:3(R)-[(2(S)-1-(tert-butoxycarbonyl)pyrrolidinylcarbonyl)amino]-2-oxo-1-(N-(N'-benzyloxycarbonylamino)ethyl)pyrrolidineacetamide

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Chemical Property of 3(R)-[(2(S)-1-(tert-butoxycarbonyl)pyrrolidinylcarbonyl)amino]-2-oxo-1-(N-(N'-benzyloxycarbonylamino)ethyl)pyrrolidineacetamide

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Technology Process of 3(R)-[(2(S)-1-(tert-butoxycarbonyl)pyrrolidinylcarbonyl)amino]-2-oxo-1-(N-(N'-benzyloxycarbonylamino)ethyl)pyrrolidineacetamide

There total 1 articles about 3(R)-[(2(S)-1-(tert-butoxycarbonyl)pyrrolidinylcarbonyl)amino]-2-oxo-1-(N-(N'-benzyloxycarbonylamino)ethyl)pyrrolidineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: {2-[2-((R)-3-Amino-2-oxo-pyrrolidin-1-yl)-acetylamino]-ethyl}-carbamic acid benzyl ester; compound with trifluoro-acetic acid

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 874163-19-6
3(R)-[(2(S)-1-(tert-butoxycarbonyl)pyrrolidinylcarbonyl)amino]-2-oxo-1-(N-(N'-benzyloxycarbonylamino)ethyl)pyrrolidineacetamide

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; for 24h; Heating;
DOI:10.1021/jm050644n

Reference yield:

: 874163-19-6
3(R)-[(2(S)-1-(tert-butoxycarbonyl)pyrrolidinylcarbonyl)amino]-2-oxo-1-(N-(N'-benzyloxycarbonylamino)ethyl)pyrrolidineacetamide

: 874163-20-9
3(R)-[(2(S)-1-(tert-butoxycarbonyl)pyrrolidinylcarbonyl)amino]-2-oxo-1-pyrrolidineacetamide N-(N'-(4-azidobenzoyl)amino)ethyl

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd/C / methanol / 24 h / 2585.74 Torr

2: 69 percent / N-methylpiperidine / acetonitrile / 18 h / Heating

With N-methylcyclohexylamine; hydrogen; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1021/jm050644n

Reference yield:

: 874163-19-6
3(R)-[(2(S)-1-(tert-butoxycarbonyl)pyrrolidinylcarbonyl)amino]-2-oxo-1-(N-(N'-benzyloxycarbonylamino)ethyl)pyrrolidineacetamide

: 874163-21-0
3(R)-[(2(S)-1-(tert-butoxycarbonyl)pyrrolidinylcarbonyl)amino]-2-oxo-1-pyrrolidineacetamide N-(N'-(4-azido-2-hydroxybenzoyl)amino)ethyl

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd/C / methanol / 24 h / 2585.74 Torr

2: 57 percent / acetonitrile / 18 h / Heating

With hydrogen; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1021/jm050644n