2-[8-(3-fluoro-2-methyl-phenyl)-6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazin-2-yl]-4-methoxy-1-(2-trimethylsilylethoxymethyl)indole-5-carbonitrile

Base Information

Chemical Name:2-[8-(3-fluoro-2-methyl-phenyl)-6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazin-2-yl]-4-methoxy-1-(2-trimethylsilylethoxymethyl)indole-5-carbonitrile
CAS No.:1420206-04-7
Molecular Formula:C₂₉H₃₃FN₄O₃Si
Molecular Weight:532.69
Hs Code.:

Synonyms:2-[8-(3-fluoro-2-methyl-phenyl)-6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazin-2-yl]-4-methoxy-1-(2-trimethylsilylethoxymethyl)indole-5-carbonitrile

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Chemical Property of 2-[8-(3-fluoro-2-methyl-phenyl)-6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazin-2-yl]-4-methoxy-1-(2-trimethylsilylethoxymethyl)indole-5-carbonitrile

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Technology Process of 2-[8-(3-fluoro-2-methyl-phenyl)-6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazin-2-yl]-4-methoxy-1-(2-trimethylsilylethoxymethyl)indole-5-carbonitrile

There total 13 articles about 2-[8-(3-fluoro-2-methyl-phenyl)-6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazin-2-yl]-4-methoxy-1-(2-trimethylsilylethoxymethyl)indole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1420205-44-2
ethyl 2-(2-chloroethoxy)-2-(3-fluoro-2-methyl-phenyl)ethanimidate

: 1420205-87-3
2-(2-chloroacetyl)-4-methoxy-1-(2-trimethylsilylethoxymethyl)indole-5-carbonitrile

: 1420206-04-7
2-[8-(3-fluoro-2-methyl-phenyl)-6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazin-2-yl]-4-methoxy-1-(2-trimethylsilylethoxymethyl)indole-5-carbonitrile

Guidance literature:: With sodium carbonate; sodium iodide; In acetone; at 20 - 50 ℃; for 88h;
DOI:10.1016/j.bmcl.2019.05.023

Reference yield:

: 1420205-49-7
6-(3-fluoro-2-methyl-phenyl)-3,6-dihydro-2H-1,4-oxazin-5-amine

: 1420205-87-3
2-(2-chloroacetyl)-4-methoxy-1-(2-trimethylsilylethoxymethyl)indole-5-carbonitrile

: 1420206-04-7
2-[8-(3-fluoro-2-methyl-phenyl)-6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazin-2-yl]-4-methoxy-1-(2-trimethylsilylethoxymethyl)indole-5-carbonitrile

Guidance literature:: With sodium carbonate; sodium iodide; In acetone; at 20 - 50 ℃;

Reference yield:

: 773094-53-4
2-(3-fluoro-2-methyl-phenyl)-1,3-dioxolane

: 1420206-04-7
2-[8-(3-fluoro-2-methyl-phenyl)-6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazin-2-yl]-4-methoxy-1-(2-trimethylsilylethoxymethyl)indole-5-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: zinc(II) iodide / dichloromethane / 1.5 h / -20 - 20 °C

2: pyridine; thionyl chloride / ethylene dibromide / 2 h / 60 °C

3: acetyl chloride / 18 h / -15 - 20 °C / Inert atmosphere

4: ammonia / methanol / 50 °C

5: sodium carbonate; sodium iodide / acetone / 20 - 50 °C

With pyridine; thionyl chloride; ammonia; sodium carbonate; acetyl chloride; sodium iodide; zinc(II) iodide; In methanol; dichloromethane; ethylene dibromide; acetone;